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Start Over Author "Catov, Janet M" Journal placenta
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2. A novel technique to estimate intravillous fetal vasculature on routine placenta histologic sections.

Author

Kozai, Andrea C., Brilli Skvarca, Lauren, Parks, William Tony, Lane, Abbi, Barone Gibbs, Bethany, and Catov, Janet M.

Abstract

Placental histopathologic lesions are dichotomized into "present" or "absent" and have limited inter-rater reliability. Continuous metrics are needed to characterize placental health and function. Tissue sections (N = 64) of human placenta were stained with CD34 antibody and hematoxylin. Proportion of the villous space occupied by fetal vascular endothelium (%FVE; pixels positive for CD34/total pixels) was evaluated for effect sizes associated with pregnancy outcomes, smoking status, and subtypes of lesions (n = 30). Time to fixation>60 min significantly increased the quantification. Large effect sizes were found between %FVE and both preterm birth and intrauterine growth restriction. These results demonstrate proof-of-concept for this vascular estimation. • Novel quantification of fetal vascular development may relate to pregnancy outcomes. • Lower vascularization may be present in cases of adverse fetal outcomes. • Quantification complements traditional histopathology. [ABSTRACT FROM AUTHOR]

Published
2024
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