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Your search keyword '"Mann, Graham"' showing total 8 results
Start Over Author "Mann, Graham" Journal pigment cell & melanoma research
8 results on '"Mann, Graham"'

2. Landscape of mutations in early stage primary cutaneous melanoma: An InterMEL study.

Author

Luo, Li, Shen, Ronglai, Arora, Arshi, Orlow, Irene, Busam, Klaus J., Lezcano, Cecilia, Lee, Tim K., Hernando, Eva, Gorlov, Ivan, Amos, Christopher, Ernstoff, Marc S., Seshan, Venkatraman E., Cust, Anne E., Wilmott, James, Scolyer, Richard A., Mann, Graham, Nagore, Eduardo, Funchain, Pauline, Ko, Jennifer, and Ngo, Peter

Subjects
TUMOR-infiltrating immune cells, MELANOMA, OLDER patients
Abstract

It is unclear why some melanomas aggressively metastasize while others remain indolent. Available studies employing multi‐omic profiling of melanomas are based on large primary or metastatic tumors. We examine the genomic landscape of early‐stage melanomas diagnosed prior to the modern era of immunological treatments. Untreated cases with Stage II/III cutaneous melanoma were identified from institutions throughout the United States, Australia and Spain. FFPE tumor sections were profiled for mutation, methylation and microRNAs. Preliminary results from mutation profiling and clinical pathologic correlates show the distribution of four driver mutation sub‐types: 31% BRAF; 18% NRAS; 21% NF1; 26% Triple Wild Type. BRAF mutant tumors had younger age at diagnosis, more associated nevi, more tumor infiltrating lymphocytes, and fewer thick tumors although at generally more advanced stage. NF1 mutant tumors were frequent on the head/neck in older patients with severe solar elastosis, thicker tumors but in earlier stages. Triple Wild Type tumors were predominantly male, frequently on the leg, with more perineural invasion. Mutations in TERT, TP53, CDKN2A and ARID2 were observed often, with TP53 mutations occurring particularly frequently in the NF1 sub‐type. The InterMEL study will provide the most extensive multi‐omic profiling of early‐stage melanoma to date. Initial results demonstrate a nuanced understanding of the mutational and clinicopathological landscape of these early‐stage tumors. [ABSTRACT FROM AUTHOR]

Published
2022
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7. Association between putative functional variants in the PSMB9 gene and risk of melanoma – re-analysis of published melanoma genome-wide association studies

Author

Qian, Ji, Liu, Hongliang, Wei, Sheng, Liu, Zhensheng, Li, Yangkai, Wang, Li-E, Chen, Wei V., Amos, Christopher I., Lee, Jeffrey E., Iles, Mark M., Law, Matthew H., Cust, Anne E., Barrett, Jennifer H., Montgomery, Grant W., Taylor, John, Bishop, Julia A. Newton, MacGregor, Stuart, Bishop, Timothy D., Mann, Graham J., Hayward, Nicholas K., and Wei, Qingyi

Published
2013
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8. MicroRNA and mRNA expression profiling in metastatic melanoma reveal associations withBRAFmutation and patient prognosis

Author

Tembe, Varsha, primary, Schramm, Sarah-Jane, additional, Stark, Mitchell S., additional, Patrick, Ellis, additional, Jayaswal, Vivek, additional, Tang, Yue Hang, additional, Barbour, Andrew, additional, Hayward, Nicholas K., additional, Thompson, John F., additional, Scolyer, Richard A., additional, Yang, Yee Hwa, additional, and Mann, Graham J., additional

Published
2015
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