1. Effect of traditional Chinese medicine on gut microbiota in adults with type 2 diabetes: A systematic review and meta-analysis
- Author
-
Min Li, Qi-You Ding, Jiaxing Tian, Xiaolin Tong, Yu-Jiao Zheng, Xiaowen Gou, and Yu Wei
- Subjects
Adult ,Blood Glucose ,medicine.medical_specialty ,endocrine system diseases ,Pharmaceutical Science ,Traditional Chinese medicine ,Type 2 diabetes ,Gut flora ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Internal medicine ,Diabetes mellitus ,Drug Discovery ,medicine ,Humans ,Medicine, Chinese Traditional ,030304 developmental biology ,Randomized Controlled Trials as Topic ,Pharmacology ,Inflammation ,0303 health sciences ,biology ,business.industry ,Therapeutic effect ,Type 2 Diabetes Mellitus ,biology.organism_classification ,medicine.disease ,Gastrointestinal Microbiome ,Complementary and alternative medicine ,Diabetes Mellitus, Type 2 ,030220 oncology & carcinogenesis ,Meta-analysis ,Molecular Medicine ,business ,Drugs, Chinese Herbal - Abstract
Background Despite advances in research on type 2 diabetes mellitus (T2DM) with the development of science and technology, the pathogenesis and treatment response of T2DM remain unclear. Recent studies have revealed a significant role of the microbiomein the development of T2DM, and studies have found that the gut microbiota may explain the therapeutic effect of traditional Chinese medicine (TCM), a primary branch of alternative and complementary medicine, in the treatment of T2DM. The aim of this study was to systematically review all randomized controlled trials (RCTs) on TCM for gut microbiota to assess the effectiveness and safety of TCM in T2DM patients. Methods All RCTs investigating the effects of TCM interventions on modulating gut microbiota and improving glucose metabolism in the treatment of T2DM adults were included. Meta-analyses were conducted when sufficient data were available, other results were reported narratively. The study protocol was pre-specified, documented, and published in PROSPERO (registration no. CRD42020188043). Results Five studies met the eligibility criteria ofthe systematic review. All five studies reported the effects of TCM interventions on the gut microbiota modulation and blood glucose control. There were statistically significant improvements in HbA1c (mean difference [MD]: -0.69%; [95% CI −0.24, −0.14]; p = 0.01, I2 = 86%), fasting blood glucose (MD: −0.87 mmol/l; [95% CI -1.26, -0.49]; p Conclusion TCM had the effect of modulating gut microbiota and improving glucose metabolisms in T2DM patients. Although the results of the included studies are encouraging, further well-conducted studies on TCM interventions targeting the gut microbiota are needed.
- Published
- 2020