1. Microbial metabolism of cannflavin A and B isolated from Cannabis sativa
- Author
-
Desmond Slade, Ikhlas A. Khan, Mahmoud A. ElSohly, Amany K. Ibrahim, Mohamed M. Radwan, Safwat A. Ahmed, and Samir A. Ross
- Subjects
medicine.drug_class ,Cannabaceae ,Antiprotozoal Agents ,Beauveria bassiana ,Microbial Sensitivity Tests ,Plant Science ,Horticulture ,Biochemistry ,Flavones ,Article ,Microbiology ,Anti-Infective Agents ,Parasitic Sensitivity Tests ,medicine ,Beauveria ,Molecular Biology ,Cannabis ,chemistry.chemical_classification ,Mucor ,Molecular Structure ,biology ,Traditional medicine ,General Medicine ,biology.organism_classification ,Antimicrobial ,chemistry ,Antiprotozoal ,Antibacterial activity - Abstract
Microbial metabolism of cannflavin A (1) and B (2), two biologically active flavonoids isolated from Cannabis sativa L., produced five metabolites (3-7). Incubation of 1 and 2 with Mucor ramannianus (ATCC 9628) and Beauveria bassiana (ATCC 13144), respectively, yielded 6''S,7''-dihydroxycannflavin A (3), 6''S,7''-dihydroxycannflavin A 7-sulfate (4) and 6''S,7''-dihydroxycannflavin A 4'-O-alpha-L-rhamnopyranoside (5), and cannflavin B 7-O-beta-D-4'''-O-methylglucopyranoside (6) and cannflavin B 7-sulfate (7), respectively. All compounds were evaluated for antimicrobial and antiprotozoal activity.
- Published
- 2010