1. Callistiviminenes A-O: Diverse adducts of β-triketone and sesqui- or monoterpene from the fruits of Callistemon viminalis.
- Author
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Wu, Lin, Wang, Xiao-bing, Li, Rui-jun, Zhang, Ya-long, Yang, Ming-hua, Luo, Jun, and Kong, Ling-Yi
- Subjects
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MONOTERPENES , *CALLISTEMON , *CHEMICAL adducts , *X-ray diffraction , *BIOSYNTHESIS - Abstract
Callistiviminenes A-O, fifteen adducts of β-triketone with sesqui- or monoterpene, along with a known compound, were isolated from the fruits of Callistemon viminalis . Callistiviminenes A and B are β-triketone-coupled (−)-bicyclosequiphellandrene contained an oxaspiro[5.5]undecene unit, and callistiviminenes C-E are rare adducts of β-triketone and bicyclogermacrene. Their structures and absolute configurations were elucidated by spectroscopic and computational methods, as well as by single-crystal X-ray diffraction experiment. A plausible biosynthetic pathway to these compounds involves a hetero-Diels–Alder reaction. Callistiviminenes C and D exhibited inhibition against lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages with IC 50 value of 20.3 μ M and 32.5 μ M, respectively. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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