1. Iridoids from leaves of Gelsemium elegans
- Author
-
Hai Liu, Bin-Feng Zhang, Zhengtao Wang, Qiu-Ping Zhang, and Gui-Xin Chou
- Subjects
Iridoid Glycosides ,Neurite ,Iridoid ,medicine.drug_class ,Stereochemistry ,Plant Science ,Horticulture ,PC12 Cells ,Biochemistry ,medicine ,Animals ,Molecule ,Glycosides ,Molecular Biology ,Molecular Structure ,biology ,Gelsemium elegans ,Chemistry ,Absolute configuration ,General Medicine ,Loganiaceae ,biology.organism_classification ,Gelsemium ,Rats ,Plant Leaves - Abstract
Six iridoids, geleganoids, designated A-F, and five iridoid glycosides, geleganosides A and B together with three previously reported compounds, were isolated from leaves of Gelsemium elegans. Their structures were elucidated by spectroscopic and chemical analyses. The relative configuration of geleganoid A was confirmed by X-ray crystallographic diffraction analysis, and the absolute configuration of geleganoid B was determined by a modified Mosher's method. Selected compounds were evaluated for PC12 cell neurite outgrowth activity, but they were inactive.
- Published
- 2011