1. Oleanane-type saponins from Glochidion glomerulatum and their cytotoxic activities.
- Author
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Thu VK, Van Thang N, Nhiem NX, Tai BH, Nam NH, Kiem PV, Minh CV, Anh HLT, Kim N, Park S, and Kim SH
- Subjects
- Antineoplastic Agents, Phytogenic chemistry, Drug Screening Assays, Antitumor, Female, HT29 Cells, Humans, Nuclear Magnetic Resonance, Biomolecular, Oleanolic Acid chemistry, Oleanolic Acid isolation & purification, Oleanolic Acid pharmacology, Plant Leaves chemistry, Saponins chemistry, Vietnam, Antineoplastic Agents, Phytogenic isolation & purification, Antineoplastic Agents, Phytogenic pharmacology, Euphorbiaceae chemistry, Oleanolic Acid analogs & derivatives, Saponins isolation & purification, Saponins pharmacology
- Abstract
Eight oleanane-type saponins, glomerulosides A-H, were isolated from leaves of Glochidion glomerulatum. All isolated compounds were evaluated for cytotoxic activity on four human cancer cell lines, A-549, HT-29, OVCAR, and MCF-7. Glomerulosides C and E, which contain a benzoyloxy group at C-22, showed significant cytotoxic activities against the A-549, HT-29, and OVCAR cancer cell lines with IC50 values ranging from 5.9 to 9.8μM. Glomeruloside A showed cytotoxicity on HT-29 and OVCAR cell lines with IC50 values of 7.3 and 6.6μM, respectively. Moreover, glomeruloside B exhibited significant activity on A-549 and HT-29 cancer cell lines with IC50 values of 9.7 and 7.5μM. In contrast, glomerulosides F-H, lacking a benzoyloxy group, showed only moderate cytotoxic activity., (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Published
- 2015
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