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Start Over Author "Zhong, Tao" Search Limiters Peer Reviewed Journal phytochemistry
13 results on '"Zhong, Tao"'

13. Lovastatin analogues and other metabolites from soil-derived Aspergillus terreus YIM PH30711.

Author

Wang, Qiang, Yang, Ya-Bin, Yang, Xue-Qiong, Miao, Cui-Ping, Li, Yi-Qing, Liu, Shi-Xi, Luo, Na, Ding, Zhong-Tao, and Zhao, Li-Xing

Subjects
*ASPERGILLUS terreus, *LOVASTATIN, *METABOLITES, *POLYKETIDES, *ACRYLIC acid
Abstract

Eight previously undescribed metabolites including of lovastatin analogues, a pair of diastereoisomers, a cyclopentenone dimer, and three polyketides were isolated from the culture of Aspergillus terreus YIM PH30711. Two types of unprecedented skeletons, benzene-cyclopentanone complex and linear polyketide, and an unusual dimer structure were determined by spectral analysis. Compound, 3α-hydroxy-3,5-dihydromonacolin L showed moderate activity against HMG-CoA reductase, with an inhibition ratio of 34% at the concentration of 50 μM, while lovastatin and dihydromonacolin K ethyl ester presented much stronger activity against HMGR with inhibition rates of 85% and 90% at the concentration of 50 μM, respectively. Aspereusin A was active against AChE with a ratio of 62% at the concentration of 50 μM, while its stereomers did not showed obvious inhibition (<10%). The configuration at C-4 of these three diastereoisomers was crucial in the inhibition against AChE, and the β -orientation of substituted methoxyl acrylic acid should be beneficial to the combining with AChE. [ABSTRACT FROM AUTHOR]

Published
2018
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