1. Cholecystokinin regulates satiation independently of the abdominal vagal nerve in a pig model of total subdiaphragmatic vagotomy
- Author
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Henk F. J. Hendriks, N. van der Wielen, Dina Ripken, S.J. Koopmans, Renger F. Witkamp, J. van der Meulen, and T. Schuurman
- Subjects
Male ,medicine.medical_treatment ,Glucose blood level ,Sus scrofa ,Biomedical Innovation ,Devazepide ,Glucagon like peptide 1 ,Behavioral Neuroscience ,Drug blood level ,Life ,Time to maximum plasma concentration ,paracetamol absorption ,Medicine ,Insulin ,Fluid intake ,exendin 9-39 ,Detacheringen ,digestive, oral, and skin physiology ,Postprandial Period ,Nutritional Biology ,Hormone response ,Postprandial ,Paracetamol ,Insulin blood level ,Autopsy ,Corporate Education ,Hormonal regulation ,medicine.medical_specialty ,Hormone Antagonists ,Research & Innovation ,Animal model ,Animal experiment ,Biology ,Glucagon-like peptide 1 ,VLAG ,Abdominal vagal nerve ,Acetaminophen ,Maximum plasma concentration ,physiological-role ,Patiety ,Subdiaphragmatic vagotomy ,afferents ,glp-1 ,Glucagon like peptide 1 receptor ,Vagotomy ,Peptide Fragments ,Stomach emptying ,Endocrinology ,Glucose ,glucagon-like peptide-1 ,Intestine motility ,Blood Glucose ,Animal Nutrition ,Food intake regulation ,Animal tissue ,Eating ,appetite control ,Food intake ,Glucagon-Like Peptide 1 ,Receptors, Glucagon ,Vagal nerve ,Cholecystokinin blood level ,Stomach absorption ,Drug absorption ,Cholecystokinin ,Vagus Nerve ,food-intake ,Diervoeding ,Models, Animal ,Healthy Living ,hormones, hormone substitutes, and hormone antagonists ,Experimental and Cognitive Psychology ,Stomach content ,Satiation ,Vagus nerve ,Glucagon-Like Peptide-1 Receptor ,Internal medicine ,Sham procedure ,Animals ,Cholecystokinin A receptor ,Weight gain ,Postprandial state ,Gastric emptying ,Vagovagal reflex ,Corporate Education, Research & Innovation ,business.industry ,Exendin (9-39) ,antagonist ,Nonhuman ,rats ,MSB - Microbiology and Systems Biology ,ELSS - Earth, Life and Social Sciences ,business ,Controlled study - Abstract
The vagal nerve and gut hormones CCK and GLP-1 play important roles in the control of food intake. However, it is not clear to what extent CCK and GLP-1 increase satiation by stimulating receptors located on abdominal vagal nerve endings or via receptors located elsewhere. This study aimed to further explore the relative contribution of the abdominal vagal nerve in mediating the satiating effects of endogenous CCK and GLP-1. Total subdiaphragmatic vagotomy or sham operation was combined with administration of CCK1 and GLP-1 receptor antagonists devazepide and exendin (9-39) in 12 pigs, applying an unbalanced Latin Square within-subject design. Furthermore, effects of vagotomy on preprandial and postprandial acetaminophen absorption, glucose, insulin, GLP-1 and CCK plasma concentrations were investigated.Ad libitum liquid meal intake (mean±SEM) was similar in sham and vagotomized pigs (4180±435 and 3760±810g/meal). Intake increased by about 20% after blockade of CCK1 receptors, independently of the abdominal vagal nerve. Food intake did not increase after blockade of GLP-1 receptors. Blockade of CCK1 and GLP-1 receptors increased circulating CCK and GLP-1 concentrations in sham pigs only, suggesting the existence of a vagal reflex mechanism in the regulation of plasma CCK1 and GLP-1 concentrations. Vagotomy decreased acetaminophen absorption and changed glucose, insulin, CCK and GLP-1 concentrations indicating a delay in gastric emptying. Our data show that at liquid feeding, satiation is decreased effectively by pharmacological blockade of CCK1 receptors. We conclude that regulation of liquid meal intake appears to be primarily regulated by CCK1 receptors not located on abdominal vagal nerve endings. Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; devazepide, 103420-77-5; glucagon like peptide 1, 89750-14-1; glucose, 50-99-7, 84778-64-3; insulin, 9004-10-8; paracetamol, 103-90-2
- Published
- 2014