1. Responsiveness and habituation of soluble ICAM-1 to acute psychosocial stress in men: determinants and effect of stress-hemoconcentration
- Author
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Daniel Preckel, Brigitte M. Kudielka, J E Fischer, and R Von Kanel
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Hydrocortisone ,Physiology ,Hemodynamics ,Blood Pressure ,Heart Rate ,Internal medicine ,Heart rate ,Adaptation, Psychological ,medicine ,Humans ,Habituation ,Habituation, Psychophysiologic ,business.industry ,Stressor ,Area under the curve ,General Medicine ,Middle Aged ,Hemoconcentration ,Intercellular Adhesion Molecule-1 ,Blood pressure ,Endocrinology ,medicine.anatomical_structure ,Area Under Curve ,Case-Control Studies ,Acute Disease ,Perception ,business ,Hypothalamic–pituitary–adrenal axis ,Stress, Psychological - Abstract
We studied the psychophysiology of soluble intercellular adhesion molecule-1 (sICAM-1) in 25 apparently healthy middle-aged men who underwent an acute psychosocial stressor three times with one week apart. Measures of the biological stress response were obtained at week one and three. The magnitude of the sICAM-1 stress response showed no habituation between individual visits. At week one, cognitive stress appraisal independently predicted integrated sICAM-1 area under the curve (AUC) between rest, immediately post-stress, and 45 min and 105 min post-stress (beta=0.67, p=0.012, deltaR(2)=0.41). Diastolic blood pressure AUC (beta=-0.45, p=0.048, deltaR(2)=0.21) and heart rate AUC (beta=0.44, p=0.055, deltaR(2)=0.21) were independent predictors of sICAM-1 AUC at week three. Adjustment for hemoconcentration yielded a decrease in sICAM-1 levels from rest to post-stress (p
- Published
- 2006