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Your search keyword '"Laurence Raehm"' showing total 4 results
Start Over Author "Laurence Raehm" Journal photodiagnosis and photodynamic therapy
4 results on '"Laurence Raehm"'

2. Functionalized mesoporous silica nanoparticles for one and two-photon photodynamic therapy

Author

Marcel Garcia, Alain Morère, Magali Gary-Bobo, J.O. Durand, Mireille Blanchard-Desce, Laurence Raehm, and Ph. Maillard

Subjects
Materials science, medicine.medical_treatment, Biophysics, Nanoparticle, Nanotechnology, Photodynamic therapy, 02 engineering and technology, Dermatology, Mesoporous silica, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Oncology, Two-photon excitation microscopy, medicine, Pharmacology (medical), 0210 nano-technology
Published
2017

3. Hyaluronic acid-functionalized mesoporous silica nanoparticles for efficient photodynamic therapy of cancer cells

Author

Magali Gary-Bobo, Marcel Garcia, Philippe Maillard, Nadia Benkirane-Jessel, Laurence Raehm, Jean-Olivier Durand, David Brevet, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Biomatériaux et ingénierie tissulaire, Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Central, Service de Chirurgie Orthopédique (UMR7561 CNRS), Inconnu, Conception, synthèse et vectorisation de biomolécules. (CSVB), Institut Curie-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), and Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]

Subjects
animal structures, medicine.medical_treatment, Biophysics, Photodynamic therapy, Apoptosis, 02 engineering and technology, Dermatology, 010402 general chemistry, Endocytosis, 01 natural sciences, chemistry.chemical_compound, Nanocapsules, Cell Line, Tumor, Hyaluronic acid, medicine, Moiety, Humans, Pharmacology (medical), Hyaluronic Acid, ComputingMilieux_MISCELLANEOUS, biology, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Chemistry, CD44, Mesoporous silica, 021001 nanoscience & nanotechnology, Silicon Dioxide, 0104 chemical sciences, Treatment Outcome, Oncology, Biochemistry, Photochemotherapy, Cell culture, Cancer cell, biology.protein, Cancer research, sense organs, 0210 nano-technology, Colorectal Neoplasms, Porosity
Abstract

Mesoporous silica nanoparticles (MSN) for photodynamic therapy (PDT) were coated with poly-(L-lysine) and hyaluronic acid (HA) by using the layer-by-layer method. HA is able to target cancer cells over-expressing the corresponding CD44 receptor. MSN functionalized with HA (MSN-HA) were more efficient than MSN without the targeting moiety when PDT was performed at low fluence (14 Jcm(-2)) and low dosage of MSN (20 μgmL(-1)) on HCT 116 colorectal cancer cells, known to over-express the CD44 receptor. Incubation of HCT-116 cancer cells with an excess of HA impaired the PDT effect with MSN-HA thus demonstrating that an active endocytosis mechanism was involved in the uptake of MSN-HA by these cells.

Published
2011

4. Functionalized mesoporous silica nanoparticles for two-photon photodynamic therapy

Author

Laurence Raehm, Magali Gary-Bobo, Olivier Mongin, Marie Maynadier, Cédric Rouxel, J.-O. Durand, Ilaria Basile, David Brevet, Youssef Mir, Mireille Blanchard-Desce, M. Garcia, and Alain Morère

Subjects
Materials science, Oncology, Two-photon excitation microscopy, medicine.medical_treatment, Biophysics, medicine, Nanoparticle, Pharmacology (medical), Nanotechnology, Photodynamic therapy, Dermatology, Mesoporous silica
Published
2011

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