1. Effectiveness of Photodynamic Therapy in Elimination of HPV-16 and HPV-18 Associated with CIN I in Mexican Women.
- Author
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Maldonado Alvarado, Elizabeth, Osorio Peralta, Martha Olivia, Moreno Vázquez, Alejandra, Martínez Guzmán, Lydia Alejandra, Melo Petrone, Maria Eugenia, Enriquez Mar, Zulma Iveth, Jovel Galdamez, Dora Estela, Carrión Solana, Bárbara, Balderas Martínez, Guadalupe, Parra, Eduarda, Castellanos Oliveros, Rossana Inés, Bello Leiva, Rosa Linda, Espinosa Montesinos, Araceli, Barrera Mendoza, Citlalli, Medina García, Selma Eugenia, and Ramón Gallegos, Eva
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PHOTODYNAMIC therapy , *PAPILLOMAVIRUS diseases , *PAPILLOMAVIRUS disease diagnosis , *WOMEN , *AMINOLEVULINIC acid , *DRUG efficacy , *DISEASES , *THERAPEUTICS - Abstract
This study aimed to determine the effectiveness of photodynamic therapy ( PDT), using δ-aminolevulinic acid (5- ALA), in the elimination of premalignant cervical lesions in Mexican patients with human papillomavirus ( HPV) infection and/or cervical intraepithelial neoplasia ( CIN). Thirty women diagnosed with CIN I and/or positive for HPV participated in the study. Topical 6% 5- ALA in gel form was applied to the uterine cervix; after 4 h, the lesion area was irradiated with a light dose of 200 J cm−2 at 635 nm. This procedure was performed three times at 48-h intervals. Clinical follow-up was performed at 3, 6, and 12 months after the initial PDT administration, by colposcopy, cervical cytology, histopathological analysis, polymerase chain reaction, and hybrid capture. Of HPV-infected patients without evidence of CIN I, 80% cleared the infection, while HPV associated with CIN I was eliminated in 83% of patients ( P < 0.05). At 12 months, CIN I had regressed in 57% of patients, although this response was not statistically significant. PDT using 6% 5- ALA is concluded to be effective in eliminating HPV infection associated or not with CIN I. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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