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N-substituted boronobenzylphosphonates were evaluated as substrates in Suzuki–Miyaura coupling catalyzed by tetrakis(triphenylphosphine)palladium(0) and complex of palladium acetate and (2-biphenyl)dicyclohexylphosphine. It was proven that they may be considered as useful substrates for the preparation of functionalized aminophosphonates.

In order to combine the properties of aza-macrocycles and aminophosphonates, a new tetraaminophosponic macrocyclic molecule has been synthesized. This potential receptor for organic molecules as well as for metal cations was obtained by condensation, hydrophosphonylation, and deprotection. The second synthetic step was performed using di(trimethylsilyl) phosphite, which enabled us to obtain the final product in high yield. NMR studies strongly suggested that the α-aminophosphonate macrocycle was reached as a symmetric meso-derivative.