1. Evidence of hyperglycemic hyperalgesia by quinpirole.
- Author
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Roane DS and Paul D
- Subjects
- Animals, Blood Glucose metabolism, Brain Chemistry drug effects, Dose-Response Relationship, Drug, Ergolines administration & dosage, Hyperglycemia physiopathology, Injections, Intraventricular, Male, Morphine pharmacology, Pain physiopathology, Quinpirole, Rats, Rats, Inbred Strains, Receptors, Opioid drug effects, Receptors, Opioid, mu, Sensory Thresholds drug effects, Dopamine Agents toxicity, Ergolines toxicity, Hyperglycemia chemically induced, Pain chemically induced
- Abstract
Male albino rats were tested for antinociception following injections (IP) with saline, quinpirole (Quin) (1 mg/kg), morphine sulfate (M.S.) (5 mg/kg), or both Quin and M.S. (1 mg/kg and 5 mg/kg, respectively). Quin reduced and M.S. increased tail-flick latency as compared to controls. Tail-flick latencies of the animals injected with both drugs were significantly reduced as compared M.S. alone. Quin increased blood glucose levels by 96 percent, as compared to saline controls. In competitive binding studies Quin displaced 3H-DAGO (IC50 = 29.8 microM). CD-1 mice demonstrated a naloxone-reversible analgesia following ICV Quin (100 micrograms). These data are consistent with the hypothesis that the hyperglycemic effects of Quin attenuate M.S. analgesia while the antinociceptive effects of Quin may be mediated through opioid receptors.
- Published
- 1992
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