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Start Over Author "Helen O. Kwanashie" Journal pharmacology
3 results on '"Helen O. Kwanashie"'

1. Subject Index Vol. 77, 2006

Author

Frédéric Lapostolle, A. Atalla, Hitoshi Sato, M. Grönig, Tamás Simor, Jeong Il Choi, Rainard Fuhr, Salman Bah, Gabriel A. Elgavish, Marcel Chauvin, Frédéric Adnet, Makoto Takayama, Pal Suranyi, J. A. Anuka, Ada Elgavish, Jean Rouaud, Anne-Elisabeth Bossard, Mireille Cantarini, Hong Beom Bae, Janet I. Ejiofor, Thomas Morris, Seok Jai Kim, Brigitta C. Brott, Nada H. Saab-Ismail, Michel Galinski, David Lockey, Chang Mo Kim, Balazs Ruzsics, K. Kuschinsky, Sung Tae Chung, Hiroaki Kohno, Brigitte Delhotal-Landes, Myung Ha Yoon, Tetsuji Ohno, Kozo Yao, Kazuhide Hasegawa, Pál Kiss, Helen O. Kwanashie, Emi Arakawa, and Yasuhiro Ina

Subjects
Pharmacology, Index (economics), Statistics, Subject (documents), General Medicine, Mathematics
Published
2006
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2. Some pregnancy-related effects of artemether in laboratory animals

Author

Janet I. Ejiofor, J. A. Anuka, and Helen O. Kwanashie

Subjects
Drug, Agonist, Male, medicine.medical_specialty, Litter Size, medicine.drug_class, Birth weight, media_common.quotation_subject, Guinea Pigs, Drug Evaluation, Preclinical, Physiology, Embryonic Development, Estrous Cycle, Biology, Oxytocin, Guinea pig, Antimalarials, Uterine Contraction, Pregnancy, Internal medicine, Animals, Laboratory, medicine, Animals, Birth Weight, Artemether, Rats, Wistar, reproductive and urinary physiology, media_common, Pharmacology, Estrous cycle, Dose-Response Relationship, Drug, General Medicine, medicine.disease, Artemisinins, Rats, Endocrinology, Fertilization, Myometrium, Female, Malaria, Injections, Intraperitoneal, medicine.drug
Abstract

Artemether, highly effective in multi-drug-resistant malaria is not routinely available for use in pregnancy due to the lack of adequate research data in animals and man. This study was therefore aimed at investigating some pregnancy-related effects of artemether. Artemether (1.5, 7.5 and 15 mg/kg i.p. daily for 7 days) did not produce changes in rat oestrous cycle. The drug did not prevent or prolong the rate of conception or parturition, cause pre-term delivery and affect litter size. Birth weight and growth rate of pups from artemether-pretreated dams were within the normal range. Artemether (48–480 µg/ml) had no agonist effect on the isolated uterine smooth muscles of both non-pregnant and pregnant rats and guinea pigs. However, the drug (24– 240 µg/ml) reduced oxytocin-induced contraction of uterine tissues concentration-dependently, particularly in pregnant uteri.

Published
2006

3. Contents Vol. 77, 2006

Author

Jean Rouaud, Ada Elgavish, Nada H. Saab-Ismail, Hong Beom Bae, Seok Jai Kim, Tetsuji Ohno, David Lockey, Hiroaki Kohno, Janet I. Ejiofor, J. A. Anuka, Sung Tae Chung, Chang Mo Kim, Frédéric Lapostolle, A. Atalla, Makoto Takayama, Tamás Simor, Kazuhide Hasegawa, Emi Arakawa, Frédéric Adnet, Pál Kiss, Jeong Il Choi, Rainard Fuhr, Gabriel A. Elgavish, Marcel Chauvin, Salman Bah, Brigitte Delhotal-Landes, K. Kuschinsky, Mireille Cantarini, M. Grönig, Pal Suranyi, Balazs Ruzsics, Myung Ha Yoon, Kozo Yao, Hitoshi Sato, Brigitta C. Brott, Michel Galinski, Anne-Elisabeth Bossard, Thomas Morris, Helen O. Kwanashie, and Yasuhiro Ina

Subjects
Pharmacology, General Medicine
Published
2006
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