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Your search keyword '"Riccardi, Carlo"' showing total 10 results
Start Over Author "Riccardi, Carlo" Journal pharmacological research
10 results on '"Riccardi, Carlo"'

1. Glucocorticoids and COVID-19

Author

Bruscoli, Stefano, primary, Puzzovio, Pier Giorgio, additional, Zaimi, Maria, additional, Tiligada, Katerina, additional, Levi-Schaffer, Francesca, additional, and Riccardi, Carlo, additional

Published
2022
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3. Glucocorticoid-induced leucine zipper modulates macrophage polarization and apoptotic cell clearance

Author

Vago, Juliana P., primary, Galvão, Izabela, additional, Negreiros-Lima, Graziele L., additional, Teixeira, Lívia C.R., additional, Lima, Kátia M., additional, Sugimoto, Michelle A., additional, Moreira, Isabella Z., additional, Jones, Sarah A., additional, Lang, Tali, additional, Riccardi, Carlo, additional, Teixeira, Mauro M., additional, Harris, James, additional, Morand, Eric F., additional, and Sousa, Lirlândia P., additional

Published
2020
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6. Selective CB2 inverse agonist JTE907 drives T cell differentiation towards a Treg cell phenotype and ameliorates inflammation in a mouse model of inflammatory bowel disease

Author

Gentili, Marco, primary, Ronchetti, Simona, additional, Ricci, Erika, additional, Di Paola, Rosanna, additional, Gugliandolo, Enrico, additional, Cuzzocrea, Salvatore, additional, Bereshchenko, Oxana, additional, Migliorati, Graziella, additional, and Riccardi, Carlo, additional

Published
2019
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10. Silymarin suppress CD4+ T cell activation and proliferation: effects on NF-kappaB activity and IL-2 production.

Author

Gharagozloo M, Velardi E, Bruscoli S, Agostini M, Di Sante M, Donato V, Amirghofran Z, and Riccardi C

Subjects
Animals, Annexin A5, Biotransformation drug effects, Blotting, Western, Cell Death drug effects, Cell Proliferation drug effects, Cells, Cultured, Enzyme-Linked Immunosorbent Assay, Mice, Mice, Inbred C57BL, Protein Transport drug effects, Spleen cytology, Transcription Factor RelA metabolism, CD4-Positive T-Lymphocytes drug effects, Immunologic Factors, Interleukin-2 biosynthesis, Lymphocyte Activation drug effects, NF-kappa B antagonists & inhibitors, NF-kappa B metabolism, Silymarin pharmacology
Abstract

Silymarin, a mixture of bioactive flavonolignans isolated from Silybum marianum, exhibits anti-carcinogenic, anti-inflammatory and cytoprotective effects. In this study, the in vitro immunomodulatory activity of silymarin was investigated using CD4+ splenocytes from C57/Bl6 mice. Proliferation assay revealed that silymarin, at 50 microM concentration, significantly inhibited CD4+ cells proliferation. ELISA analyses indicated that silymarin significantly inhibited IL-2 and IFN-gamma production. Immunofluorescence staining performed on the mouse hybridoma T cell line (3DO) revealed a block of nuclear translocation of transcription factor kappaB (NF-kappaB), which is known to be responsible for IL-2 transcriptional activation. Moreover, silymarin inhibited p65/NF-kappaB phosphorylation in CD4+ T cell. These results suggest that silymarin is able to inhibit T cell activation and proliferation, notably acting on pathways of NF-kappaB activation/translocation., ((c) 2010 Elsevier Ltd. All rights reserved.)

Published
2010
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