1. Oleoylethanolamide inhibits food intake in free-feeding rats after oral administration
- Author
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Oveisi, Fariba, Gaetani, Silvana, Eng, Kevin Tai-Pang, and Piomelli, Daniele
- Subjects
Neurosciences ,Digestive Diseases ,Nutrition ,Oral and gastrointestinal ,Administration ,Oral ,Animals ,Appetite Depressants ,Capsules ,Drug Evaluation ,Preclinical ,Eating ,Endocannabinoids ,Feeding Behavior ,Forecasting ,Gastrointestinal Tract ,Intubation ,Gastrointestinal ,Liver ,Male ,Oleic Acids ,Rats ,Rats ,Wistar ,Solubility ,Time Factors ,Tissue Distribution ,meal pattern ,enteric coating ,Pharmacology and Pharmaceutical Sciences ,Pharmacology & Pharmacy - Abstract
Oleoylethanolamide (OEA) is an endogenous lipid that contributes in important ways to the peripheral regulation of food intake. When administered intraperitoneally, OEA is a potent satiety-inducing anorexiant in rats and mice [Nature 414 (2001) 209; Neuropsycopharmacology 28 (2003) 1311; Nature 425 (2003) 90]. In the present study, we show that oral administration of OEA in pH-sensitive enteric-coated capsules produces a profound and long-lasting inhibition of food intake in free-feeding rats. This effect is accompanied by a marked elevation in OEA levels in the small intestine, but not in brain or muscle.
- Published
- 2004