1. CYP3A5 and ABCB1 polymorphisms in living donors do not impact clinical outcome after kidney transplantation.
- Author
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Yang L, de Winter BC, van Schaik RH, Xie RX, Li Y, Andrews LM, Shuker N, Bahmany S, Koch B, van Gelder T, and Hesselink DA
- Subjects
- ATP Binding Cassette Transporter, Subfamily B genetics, Adult, Aged, Aged, 80 and over, Female, Genotype, Glomerular Filtration Rate drug effects, Glomerular Filtration Rate genetics, Humans, Immunosuppressive Agents therapeutic use, Kidney Transplantation methods, Living Donors, Male, Middle Aged, Polymorphism, Single Nucleotide drug effects, Tacrolimus therapeutic use, Young Adult, Cytochrome P-450 CYP3A genetics, Polymorphism, Single Nucleotide genetics
- Abstract
Aim: To investigate the association between donor CYP3A5 and ABCB1 polymorphisms and tacrolimus (Tac)-induced nephrotoxicity and renal function in kidney transplant recipients., Methods: The CYP3A5 6986A>G and ABCB1 3435C>T polymorphisms were determined in 237 recipients and donors., Results: There was no significant association between Tac-related nephrotoxicity and donor CYP3A5 and ABCB1 genotype. The donor ABCB1 3435C>T polymorphism was associated with estimated glomerular filtration rate on day 7 and month 1. The combined donor-recipient ABCB1 genotype (3435C>T polymorphism) was significantly related with estimated glomerular filtration rate on day 3 and 7 in univariate analysis. However, these differences were no longer statistically significant in multivariate analysis., Conclusion: A genetic analysis of ABCB1 and CYP3A5 of kidney transplant donors is not helpful to improve renal transplant outcomes.
- Published
- 2018
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