1. Clinical and genetic risk factors for the prediction of hepatotoxicity induced by a docetaxel, epirubicin and cyclophosphamide regimen in breast cancer patients
- Author
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Jing Yang, Chuan Wang, Danni Xiao, Maobai Liu, Xiaoxiong Guo, Shunmin Huang, Hongfu Cai, Fangmeng Fu, and Baochang He
- Subjects
0301 basic medicine ,Oncology ,Docetaxel ,0302 clinical medicine ,Non-alcoholic Fatty Liver Disease ,Risk Factors ,Antineoplastic Combined Chemotherapy Protocols ,Genotype ,Nonalcoholic fatty liver disease ,ATP Binding Cassette Transporter, Subfamily G, Member 2 ,Medicine ,Antibiotics, Antineoplastic ,virus diseases ,hemic and immune systems ,Middle Aged ,Neoplasm Proteins ,030220 oncology & carcinogenesis ,Molecular Medicine ,Female ,Chemical and Drug Induced Liver Injury ,tissues ,Epirubicin ,medicine.drug ,Adult ,medicine.medical_specialty ,Cyclophosphamide ,education ,Breast Neoplasms ,Polymorphism, Single Nucleotide ,03 medical and health sciences ,Breast cancer ,Internal medicine ,Genetics ,Humans ,Genetic Testing ,Antineoplastic Agents, Alkylating ,Retrospective Studies ,Pharmacology ,Polymorphism, Genetic ,Superoxide Dismutase ,business.industry ,medicine.disease ,Antineoplastic Agents, Phytogenic ,respiratory tract diseases ,Regimen ,030104 developmental biology ,Case-Control Studies ,Gene polymorphism ,business - Abstract
Aim: To screen clinical and genetic risk factors and examine their combined effect on docetaxel, epirubicin and cyclophosphamide (TEC) regimen-induced liver injury (TEC-ILI). Patients & methods: We enrolled 396 breast cancer patients, and TEC-ILI-associated factors were screened by logistic regression analyses. Results: SOD2 rs4880 and ABCG2 rs2231142 polymorphisms correlated with an increased risk of TEC-ILI. Multivariate analysis incorporating clinical and genetic factors revealed that ABCC1 rs246221 (CC) and SOD2 rs4880 (AG/GG) increased the risk of TEC-ILI. Patients with at least two risk factors among nonalcoholic fatty liver disease, high low-density lipoproteinemia levels and the rs246221 or rs4880 adverse genotypes exhibited a significantly increased risk of developing TEC-ILI. Conclusion: The combination of clinical and genetic risk factors had higher predictive value for TEC-ILI than the interclinical risk factors alone.
- Published
- 2021
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