1. Effects of rare CYP2C9 alleles on stable warfarin doses in Chinese Han patients with atrial fibrillation
- Author
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Hua-Lan Wu, Xinlong Zhao, Jiefu Yang, Jia Chong, Anxu Zhao, Da-Peng Dai, You Lü, Dongxu Wang, Hao Chen, and Ruoyun Yin
- Subjects
Pharmacology ,Univariate analysis ,medicine.medical_specialty ,business.industry ,Warfarin ,Retrospective cohort study ,Atrial fibrillation ,030204 cardiovascular system & hematology ,medicine.disease ,030226 pharmacology & pharmacy ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Genetics ,medicine ,Molecular Medicine ,cardiovascular diseases ,Dosing ,Gene polymorphism ,Allele ,business ,CYP2C9 ,medicine.drug - Abstract
Aim: Gene polymorphisms are critical in warfarin dosing variation. Here, the role of rare CYP2C9 alleles on warfarin doses in Chinese Han patients was investigated. Methods: A retrospective study recruited 681 warfarin treated atrial fibrillation patients. The genetic and clinical data were collected. Dose-related variables were selected by univariate analyses and the warfarin-dosing algorithm was derived by multivariate regression analysis. Results: Three rare CYP2C9 alleles ( CYP2C9*13, *16 and *60) were associated with lower stable doses. Inclusion of the rare CYP2C9 alleles in the prediction model added an extra 3.7% warfarin dose predictive power. Conclusion: CYP2C9*13, *16 and *60 was associated with lower stable warfarin doses in Chinese patients. The algorithm including rare CYP2C9 alleles tends to more accurately predict stable warfarin doses.
- Published
- 2020