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Your search keyword '"Owen, Andrew"' showing total 16 results
Start Over Author "Owen, Andrew" Journal pharmacogenetics and genomics
16 results on '"Owen, Andrew"'

7. Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS

Author

Liptrott, Neill J., primary, Pushpakom, Sudeep, additional, Wyen, Christoph, additional, Fätkenheuer, Gerd, additional, Hoffmann, Christian, additional, Mauss, Stefan, additional, Knechten, Heribert, additional, Brockmeyer, Norbert H., additional, Hopper-Borge, Elizabeth, additional, Siccardi, Marco, additional, Back, David J., additional, Khoo, Saye H., additional, Pirmohamed, Munir, additional, and Owen, Andrew, additional

Published
2012
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8. Maraviroc is a substrate for OATP1B1 in vitro and maraviroc plasma concentrations are influenced by SLCO1B1 521 T>C polymorphism

Author

Siccardi, Marco, primary, D'Avolio, Antonio, additional, Nozza, Silvia, additional, Simiele, Marco, additional, Baietto, Lorena, additional, Stefani, Francesca Romana, additional, Moss, Darren, additional, Kwan, Wai-San, additional, Castagna, Antonella, additional, Lazzarin, Adriano, additional, Calcagno, Andrea, additional, Bonora, Stefano, additional, Back, David, additional, Di Perri, Giovanni, additional, and Owen, Andrew, additional

Published
2010
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9. HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms

Author

Hartkoorn, Ruben C., primary, Kwan, Wai San, additional, Shallcross, Victoria, additional, Chaikan, Ammara, additional, Liptrott, Neill, additional, Egan, Deirdre, additional, Sora, Enrique Salcedo, additional, James, Chloë E., additional, Gibbons, Sara, additional, Bray, Pat G., additional, Back, David J., additional, Khoo, Saye H., additional, and Owen, Andrew, additional

Published
2010
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10. Tacrine-induced liver damage: an analysis of 19 candidate genes

Author

Alfirevic, Ana, primary, Mills, Tracy, additional, Carr, Daniel, additional, Barratt, Bryan J., additional, Jawaid, Ansar, additional, Sherwood, James, additional, Smith, John C., additional, Tugwood, Jonathan, additional, Hartkoorn, Ruben, additional, Owen, Andrew, additional, Park, Kevin B., additional, and Pirmohamed, Munir, additional

Published
2007
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13. RXRgene variants are associated with HIV lipodystrophy

Author

Pushpakom, Sudeep P., Owen, Andrew, Back, David J., and Pirmohamed, Munir

Abstract

HIV lipodystrophy (HIVLD), associated with combination antiretroviral therapy (cART), leads to metabolic and cardiovascular diseases. Nuclear receptors play a central role in lipid homoeostasis and drug disposition; their genetic variants may predispose an individual to the development of HIVLD. DNA samples obtained from cART-treated HIV-positive patients with (HIVLD; 124) and without (HIVLD−; 56) HIVLD were genotyped for 77 single nucleotide polymorphisms in nine nuclear receptor genes. Statistical analysis was carried out using Haploview software and by logistic regression. Three single nucleotide polymorphisms in RXR(rs2134095, rs113471, rs2194899) and its haplotypes (HIVLD, 54; HIVLD−, 40.6; P=0.02) showed significant association with HIVLD. Multivariate analysis identified time since diagnosis (P=0.001) and carriage of the RXRhaplotype (P=0.02) to be independently associated with HIVLD. Genetic variation in RXR, a common binding partner of nuclear receptors that modulate lipid homoeostasis and drug disposition, may contribute to the development of HIVLD in cART-treated HIV patients. These results need replication in other cohorts.

Published
2013

14. Association of ABCC10polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIVAIDS

Author

Liptrott, Neill J., Pushpakom, Sudeep, Wyen, Christoph, Fätkenheuer, Gerd, Hoffmann, Christian, Mauss, Stefan, Knechten, Heribert, Brockmeyer, Norbert H., Hopper-Borge, Elizabeth, Siccardi, Marco, Back, David J., Khoo, Saye H., Pirmohamed, Munir, and Owen, Andrew

Abstract

Nevirapine exhibits marked interpatient variability in pharmacokinetics. CYP2B6 activity and demographic factors are important, but there are a few data on drug transporters for nevirapine. ABCC10 (MRP7) is an efflux transporter highly expressed in liver, intestine, and peripheral blood cells. We investigated whether nevirapine is a substrate for ABCC10 and whether genetic variants contribute to variability in nevirapine plasma concentrations.

Published
2012
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15. Adipogenic gene variants in patients with HIV-associated lipodystrophy

Author

Pushpakom, Sudeep P., Owen, Andrew, Vilar, Castro, Hannah, Dunn, David T., Back, David J., and Pirmohamed, Munir

Abstract

Although highly active antiretroviral therapy (HAART) has been hugely beneficial in the treatment of HIV, HIV lipodystrophy (HIVLD) associated with HAART isaserious adverse effect, with long-term consequences including metabolic disturbances and an increased risk of atherosclerotic disease. Although HIVLD is clearly related to the drug regimen, individual susceptibility also plays a role. We hypothesized that variation in genes regulating adipogenesis, and in those implicated in inherited forms oflipodystrophy, may predispose to the development of HIVLD.

Published
2011
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16. Maraviroc is a substrate for OATP1B1 in vitroand maraviroc plasma concentrations are influenced by SLCO1B1 521 T>C polymorphism

Author

Siccardi, Marco, D'Avolio, Antonio, Nozza, Silvia, Simiele, Marco, Baietto, Lorena, Stefani, Francesca Romana, Moss, Darren, Kwan, Wai-San, Castagna, Antonella, Lazzarin, Adriano, Calcagno, Andrea, Bonora, Stefano, Back, David, Di Perri, Giovanni, and Owen, Andrew

Abstract

Organic anion transporting polypeptides (OATPs) are emerging as major determinants of pharmacokinetics for numerous drugs, with the 1B1 isoform-mediating hepatic uptake. The 521 T>C polymorphism has been correlated earlier with higher plasma concentrations of several drugs and the aim of this study was to determine whether this polymorphism influences trough concentrations of maraviroc.

Published
2010
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