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Start Over Author "Trombino, Sonia" Journal pharmaceutics
10 results on '"Trombino, Sonia"'

7. Development and Translation of NanoBEO, a Nanotechnology-Based Delivery System of Bergamot Essential Oil Deprived of Furocumarins, in the Control of Agitation in Severe Dementia

Author

Scuteri, Damiana, primary, Cassano, Roberta, additional, Trombino, Sonia, additional, Russo, Rossella, additional, Mizoguchi, Hirokazu, additional, Watanabe, Chizuko, additional, Hamamura, Kengo, additional, Katsuyama, Soh, additional, Komatsu, Takaaki, additional, Morrone, Luigi Antonio, additional, Rombolà, Laura, additional, Adornetto, Annagrazia, additional, Laganà, Annarita S., additional, Corasaniti, Maria Tiziana, additional, Tonin, Paolo, additional, Sakurada, Shinobu, additional, Sakurada, Tsukasa, additional, Nicotera, Pierluigi, additional, and Bagetta, Giacinto, additional

Published
2021
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10. Novel Nanoparticles Based on N , O -Carboxymethyl Chitosan-Dopamine Amide Conjugate for Nose-to-Brain Delivery.

Author

Trapani, Adriana, Cometa, Stefania, De Giglio, Elvira, Corbo, Filomena, Cassano, Roberta, Di Gioia, Maria Luisa, Trombino, Sonia, Hossain, Md Niamat, Di Gioia, Sante, Trapani, Giuseppe, and Conese, Massimo

Subjects
BLOOD-brain barrier, X-ray photoelectron spectroscopy, INTRANASAL administration, CHEMICAL stability, PARKINSON'S disease, DOPAMINERGIC neurons, DOPAMINE, DOPAMINE receptors
Abstract

A widely investigated approach to bypass the blood brain barrier is represented by the intranasal delivery of therapeutic agents exploiting the olfactory or trigeminal connections nose-brain. As for Parkinson's disease (PD), characterized by dopaminergic midbrain neurons degeneration, currently there is no disease modifying therapy. Although several bio-nanomaterials have been evaluated for encapsulation of neurotransmitter dopamine (DA) or dopaminergic drugs in order to restore the DA content in parkinsonian patients, the premature leakage of the therapeutic agent limits this approach. To tackle this drawback, we undertook a study where the active was linked to the polymeric backbone by a covalent bond. Thus, novel nanoparticles (NPs) based on N,O-Carboxymethylchitosan-DA amide conjugate (N,O-CMCS-DA) were prepared by the nanoprecipitation method and characterized from a technological view point, cytotoxicity and uptake by Olfactory Ensheating Cells (OECs). Thermogravimetric analysis showed high chemical stability of N,O-CMCS-DA NPs and X-ray photoelectron spectroscopy evidenced the presence of amide linkages on the NPs surface. MTT test indicated their cytocompatibility with OECs, while cytofluorimetry and fluorescent microscopy revealed the internalization of labelled N,O-CMCS-DA NPs by OECs, that was increased by the presence of mucin. Altogether, these findings seem promising for further development of N,O-CMCS-DA NPs for nose-to-brain delivery application in PD. [ABSTRACT FROM AUTHOR]

Published
2022
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