1. Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry
- Author
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Rajendran, Gayathri, Bhanu, Deepu, Aruchamy, Baladhandapani, Ramani, Prasanna, Pandurangan, Nanjan, Bobba, Kondapa Naidu, Oh, Eun Jung, Chung, Ho Yun, Gangadaran, Prakash, and Ahn, Byeong-Cheol
- Subjects
Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Infectious Diseases ,Good Health and Well Being ,chalcones ,natural sources ,Claisen-Schmidt condensation ,infectious diseases ,non-infectious diseases ,structure-activity relationship ,Claisen–Schmidt condensation ,structure–activity relationship ,Pharmacology and pharmaceutical sciences - Abstract
Chalcones are a class of privileged scaffolds with high medicinal significance due to the presence of an α,β-unsaturated ketone functionality. Numerous functional modifications of chalcones have been reported, along with their pharmacological behavior. The present review aims to summarize the structures from natural sources, synthesis methods, biological characteristics against infectious and non-infectious diseases, and uses of chalcones over the past decade, and their structure-activity relationship studies are detailed in depth. This critical review provides guidelines for the future design and synthesis of various chalcones. In addition, this could be highly supportive for medicinal chemists to develop more promising candidates for various infectious and non-infectious diseases.
- Published
- 2022