1. Nanoemulsifying drug delivery system to improve the bioavailability of piroxicam
- Author
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Thanaa Mohamed Borg, Abd El-Gawad, Amira Motawea, and Manal Tarshoby
- Subjects
Drug ,Surface Properties ,Drug Compounding ,media_common.quotation_subject ,Administration, Oral ,Biological Availability ,Pharmaceutical Science ,02 engineering and technology ,Piroxicam ,030226 pharmacology & pharmacy ,Surface-Active Agents ,03 medical and health sciences ,0302 clinical medicine ,Microscopy, Electron, Transmission ,Pharmacokinetics ,medicine ,Humans ,Plant Oils ,Dissolution testing ,Particle Size ,Solubility ,Dissolution ,media_common ,Drug Carriers ,Chromatography ,Dose-Response Relationship, Drug ,Chemistry ,Anti-Inflammatory Agents, Non-Steroidal ,General Medicine ,021001 nanoscience & nanotechnology ,Soybean Oil ,Bioavailability ,Area Under Curve ,Drug delivery ,Coconut Oil ,Nanoparticles ,Emulsions ,0210 nano-technology ,Tablets ,medicine.drug - Abstract
The aim of this study is to develop and characterize self-nanoemulsifying drug delivery system (SNEDDS) of piroxicam in liquid and solid forms to improve its dissolution, absorption and therapeutic efficacy.The generation of liquid SNEDDS (L-SNEDDS) was composed of soybean or coconut oil/Tween 80/Transcutol HP (12/80/8%w/w) and it was selected as the optimized formulation based on the solubility study and pseudo-ternary phase diagram. Optimized L-SNEDDS and liquid supersaturatable SNEDDS (L-sSNEDDS) preparations were then adsorbed onto adsorbents and formulated as directly compressed tablets.The improved drug dissolution rate in the solid supersaturatable preparation (S-sSNEDDS) may be due to the formation of a nanoemulsion and the presence of drug in an amorphous state with hydrogen bond interaction between the drug and SNEDDS components. In vivo pharmacokinetic studies on eight healthy human volunteers showed a significant improvement in the oral bioavailability of piroxicam from S-sSNEDDS (F12) compared with both the pure drug (PP) and its commercial product (FeldeneThe obtained results ratify that S-sSNEDDS is a promising drug delivery system to enhance the oral bioavailability of piroxicam.
- Published
- 2016