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Start Over Author "A. N. Stukov" Journal pharmaceutical chemistry journal
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2. Synthesis, Immunomodulating and Antitumor Activities of Copolymers of Dialkylaminoethyl Methacrylates and Vinylsaccharides

Author

Yu. I. Zolotova, Olga V. Nazarova, A. N. Stukov, O. N. Zhuravskaya, T. N. Nekrasova, E. F. Panarin, and L. S. Potapenkova

Subjects
Pharmacology, Chemistry, Pharmacology toxicology, 02 engineering and technology, Carbohydrate, 021001 nanoscience & nanotechnology, Sorbose, Methacrylate, chemistry.chemical_compound, 020303 mechanical engineering & transports, 0203 mechanical engineering, Drug Discovery, Copolymer, Organic chemistry, 0210 nano-technology
Abstract

Water-soluble random copolymers of N,N-(dimethylamino)ethyl methacrylate or N,N-(diethylamino)ethyl methacrylate with vinylsaccharides (N-methacryloyl aminoglucose, 3-O-methacryloyl glucose, 1-O-methacryloyl sorbose) were synthesized. The copolymers differed in composition, structure of the carbohydrate fragment, and type of carbohydrate–main-polymer-chain bonds. The immunomodulating activity and antitumor properties of the synthesized copolymers were established. Copolymers containing sorbose residues possessed the most pronounced immunodepressant properties.

Published
2017
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