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Some novel derivatives of quinazolinone including 2-[2-(2, 6-dichlorophenyl)amino]phenylmethyl-3-{4-[2-(substituted phenyl)-4-oxo-thiazolidin-3-yl]phenylsulfonamido-1-yl}-6-bromoquinazolin-4(3 H)ones ( 4a - 4l) were prepared from 2-[2-(2, 6-dichlorophenyl) amino]phenylmethyl-3-{[4-( N-substituted arylidene)phenyl]-sulfonamide-1-yl}-6-bromo quinazolin-4(3 H)ones ( 3a - 3l). Twenty four synthesized compounds were screened in vitro for their antibacterial and antifungal activities. Minimum inhibitory concentration (MIC) values of all the twenty four compounds were determined. Some of these compounds exhibited significant antimicrobial activity. [ABSTRACT FROM AUTHOR]

The title compounds VIa – j have been prepared from the lead molecule 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid I. The lead molecule was converted to hydrazide III via acid chloride II, which on reaction with different substituted aromatic aldehydes a – j afforded Schiff base, and on further structural variation of the Schiff base furnished the final compounds VIa – j ( Scheme I). The synthesized compounds were tested for their antibacterial and antifungal activity (MIC) in vitro against two Gram-positive bacteria, S. aureus and S. pyogenes, and two Gram-negative bacteria E. coli and P. aeruginosa, and fungi C. albicans, A. niger, and A. clavatus, taking gentamycin, ampicillin, chloramphenicol, ciprofloxacin, norfloxacin, nystatin, and griseofulvin as standard drugs. All the synthesized compounds have been established by elemental analysis amd IR and NMR spectral data. [ABSTRACT FROM AUTHOR]

Mixed-ligand complexes of the type [M(SB)2acphen], where M = Mn(II), Co(II), Ni(II), Cu(II), and Cd(II), HSB = 3,5-dibromosalicylideneaniline, and acphen = bis(acetophenone)ethylenediamine, have been prepared and characterized on the basis of elemental analyses, magnetic measurements, thermogravimetry, and infrared and electronic absorption spectroscopy. All the mixed-ligand complexes exhibit an octahedral geometry. The mixed-ligand complexes show antimicrobial activities against bacteria, yeast, and fungi. [ABSTRACT FROM AUTHOR]