1. Curcumin suppresses inflammatory cytokines and heat shock protein 70 release and improves metabolic parameters during experimental sepsis
- Author
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Letycia Silvano da Silva, Carlos Henrique Rocha Catalão, Tatiana Tocchini Felippotti, Gabriela Ravanelli de Oliveira- Pelegrin, Sérgio Petenusci, Luis Alexandre Pedro de Freitas, and Maria José Alves Rocha
- Subjects
clp ,hsp70 ,nitric oxide ,glycaemia ,volemia ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Context: Curcumin has been reported to have anti-inflammatory, antioxidant and hypoglycaemic properties, besides reducing mortality in sepsis. Objective: This study evaluates the biological activities of a curcumin dispersion formulated by spray-drying in experimental sepsis. Materials and methods: Male Wistar rats were subjected to sepsis by caecal ligation and puncture (CLP), controls were sham operated. The animals were treated with curcumin dispersion (100 mg/kg, p.o.) or water for 7 days prior to CLP and at 2 h after surgery. One group was used to analyze curcumin absorption through HPLC; another had the survival rate assessed during 48 h; and from a third group, blood was collected by decapitation to analyze metabolic and inflammatory parameters. Results: The plasma curcumin levels reached 2.5 ng/mL at 4 h, dropped significantly (p
- Published
- 2017
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