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To address the issue of horizontal well production affected by the distribution of perforation density in the wellbore, a numerical model for simulating two-phase flow in a horizontal well is established under two perforation density distribution conditions (i.e. increasing the perforation density at inlet and outlet sections respectively). The simulation results are compared with experimental results to verify the reliability of the numerical simulation method. The behaviors of the total pressure drop, superficial velocity of air-water two-phase flow, void fraction, liquid film thickness, air production and liquid production that occur with various flow patterns are investigated under two perforation density distribution conditions based on the numerical model. The total pressure drop, superficial velocity of the mixture and void fraction increase with the air flow rate when the water flow rate is constant. The liquid film thickness decreases when the air flow rate increases. The liquid and air productions increase when the perforation density increases at the inlet section compared with increasing the perforation density at the outlet section of the perforated horizontal wellbore. It is noted that the air production increases with the air flow rate. Liquid production increases with the bubble flow and begins to decrease at the transition point of the slug-stratified flow, then increases through the stratified wave flow. The normalized liquid flux is higher when the perforation density increases at the inlet section, and increases with the radial air flow rate. [ABSTRACT FROM AUTHOR]