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10. Total-Body PET Imaging of Musculoskeletal Disorders

Author

Chaudhari, Abhijit J, Raynor, William Y, Gholamrezanezhad, Ali, Werner, Thomas J, Rajapakse, Chamith S, and Alavi, Abass

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Osteoporosis, Biomedical Imaging, Bioengineering, 4.2 Evaluation of markers and technologies, 4.1 Discovery and preclinical testing of markers and technologies, Musculoskeletal, Humans, Musculoskeletal Diseases, Musculoskeletal System, Positron-Emission Tomography, Whole Body Imaging, Arthritis, Fever of unknown origin, Sarcopenia, Cancer, Osteosarcoma, PET/CT, PET/MR imaging, Nuclear Medicine & Medical Imaging, Oncology and carcinogenesis
Abstract

Imaging of musculoskeletal disorders, including arthritis, infection, osteoporosis, sarcopenia, and malignancies, is often limited when using conventional modalities such as radiography, computed tomography (CT), and MR imaging. As a result of recent advances in Positron Emission Tomography (PET) instrumentation, total-body PET/CT offers a longer axial field-of-view, higher geometric sensitivity, and higher spatial resolution compared with standard PET systems. This article discusses the potential applications of total-body PET/CT imaging in the assessment of musculoskeletal disorders.

Published
2021

11. Potential Roles of Total-Body PET/Computed Tomography in Pediatric Imaging

Author

Nardo, Lorenzo, Schmall, Jeffrey P, Werner, Thomas J, Malogolowkin, Marcio, Badawi, Ramsey D, and Alavi, Abass

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Biomedical Imaging, Pediatric, Bioengineering, 4.1 Discovery and preclinical testing of markers and technologies, 4.2 Evaluation of markers and technologies, Good Health and Well Being, Child, Humans, Neoplasms, Positron Emission Tomography Computed Tomography, Radiation Dosage, Time, Whole Body Imaging, Total body, PET, Computed tomography, Pediatrics, Nuclear Medicine & Medical Imaging, Oncology and carcinogenesis
Abstract

In the current diagnostic paradigm, the substantial physical sensitivity gain is the main advantage of total-body (TB) PET/computed tomography (CT). Therefore, it is up to the imaging community to tailor protocols that take advantage of this unique innovation as it relates to the needs of the pediatric population. However, the paradigm-shifting promise of TB-PET/CT lies in its capability to perform dynamic, delayed, and low-dose imaging, which have the potential to vastly increase the range of diseases and disorders that can be investigated or managed using molecular imaging.

Published
2020

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