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3. Anti-inflammatory effects of moxifloxacin and human beta-defensin 2 association in human lung epithelial cell line (A549) stimulated with lipopolysaccharide.

Author

Donnarumma G, Paoletti I, Buommino E, Iovene MR, Tudisco L, Cozza V, and Tufano MA

Subjects
Cell Adhesion drug effects, Cell Line, Cytokines genetics, Cytokines metabolism, Epithelial Cells drug effects, Epithelial Cells metabolism, Fluoroquinolones, Gene Expression drug effects, Humans, Inflammation drug therapy, Intercellular Adhesion Molecule-1 genetics, Intercellular Adhesion Molecule-1 metabolism, Interleukin-1beta genetics, Interleukin-1beta metabolism, Interleukin-6 genetics, Interleukin-6 metabolism, Interleukin-8 genetics, Interleukin-8 metabolism, Lipopolysaccharides metabolism, Lipopolysaccharides pharmacology, Lung cytology, Moxifloxacin, Neutrophils drug effects, Tumor Necrosis Factor-alpha genetics, Tumor Necrosis Factor-alpha metabolism, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Aza Compounds pharmacology, Quinolines pharmacology, beta-Defensins pharmacology
Abstract

Epithelia in the human airways, from the nasal aperture to the alveoli, are covered in a protective film of fluid containing a number of antimicrobial proteins. Defensins are single-chain, strongly cationic peptides and are one of the most extensively studied classes of antimicrobial peptides. Moxifloxacin (MXF) is a fluoroquinolone that acts against both Gram positive and Gram negative bacteria. In this study, we evaluated the effects of HBD2, MXF and the association MXF/HBD2 on some cytokines and on the ICAM-1 expression in LPS-stimulated A549 cells. Our results suggest that by lowering the epithelial cell-derived IL-1beta, IL-6, IL-8 and ICAM-1 expression, the MXF/HBD2 association interferes with the multifunctional cytokine network evolving during inflammatory processes of the respiratory tract; this anti-inflammatory potential could be of great value in the treatment of inflammatory disorders.

Published
2007
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