1. Construction, internal validation and implementation in a mobile application of a scoring system to predict nonadherence to proton pump inhibitors
- Author
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Emma Mares-García, Antonio Palazón-Bru, David Manuel Folgado-de la Rosa, Avelino Pereira-Expósito, Álvaro Martínez-Martín, Ernesto Cortés-Castell, and Vicente Francisco Gil-Guillén
- Subjects
Proton pump inhibitors ,Medication adherence ,Patient compliance ,Statistical models ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
Background Other studies have assessed nonadherence to proton pump inhibitors (PPIs), but none has developed a screening test for its detection. Objectives To construct and internally validate a predictive model for nonadherence to PPIs. Methods This prospective observational study with a one-month follow-up was carried out in 2013 in Spain, and included 302 patients with a prescription for PPIs. The primary variable was nonadherence to PPIs (pill count). Secondary variables were gender, age, antidepressants, type of PPI, non-guideline-recommended prescription (NGRP) of PPIs, and total number of drugs. With the secondary variables, a binary logistic regression model to predict nonadherence was constructed and adapted to a points system. The ROC curve, with its area (AUC), was calculated and the optimal cut-off point was established. The points system was internally validated through 1,000 bootstrap samples and implemented in a mobile application (Android). Results The points system had three prognostic variables: total number of drugs, NGRP of PPIs, and antidepressants. The AUC was 0.87 (95% CI [0.83–0.91], p
- Published
- 2017
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