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A report from the Murdoch Children's Research Institute in Victoria, Australia, discusses the genetic contributions to infertility in pediatric cancer survivors. The study conducted a systematic review of pharmacogenomic studies that examined the interactions between cancer treatment, genetic predisposition, and fertility outcomes. Eight articles were reviewed, and a total of 29 genes were analyzed. The research concluded that larger, prospective longitudinal studies are needed to replicate significant findings and apply them clinically. [Extracted from the article]

A recent study conducted by La Trobe University in Melbourne, Australia, explored the feasibility of a 10-week intervention called CanMOVE, which aimed to promote physical activity among children and adolescents undergoing acute cancer treatment. The study found that CanMOVE was well-received by participants and met the feasibility thresholds for implementation. Positive effects were observed in terms of physical activity behavior, physical function, and health-related quality of life. The researchers concluded that CanMOVE is suitable for further testing in a large-scale trial. [Extracted from the article]

A recent study conducted at the Royal Children's Hospital in Victoria, Australia, examined the infection risks associated with chimeric antigen receptor T-cell (CAR-T) therapy in pediatric patients with relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL). The study found that the majority of patients received comprehensive infectious diseases reviews prior to CAR-T therapy, which informed personalized prophylaxis plans. Overall, 22% of patients experienced one or more infections, with bacterial bloodstream infections being the most common. The study suggests that the prophylaxis recommendations used in this population are effective. [Extracted from the article]