1. Impact of antipyretics on acute asthma exacerbation during respiratory infection—A nationwide population-based study
- Author
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Ruei-Sian Chung, Yung-Chieh Huang, Yi-Huei Chen, Lin-Shien Fu, and Ching-Heng Lin
- Subjects
asthma exacerbation (AE) ,acetaminophen ,NSAID COX-1 ,Pediatrics ,RJ1-570 - Abstract
Background: Antipyretics are frequently used in pediatric practice. Both acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to increase the risk of asthma exacerbation. The study investigated antipyretic use during respiratory infection in children and analyzed the risk of acetaminophen and NSAID for severe asthma exacerbation (AE) in asthmatic children in Taiwan. Methods: We used the data from the National Health Insurance Research Database in 2005. There were 27,095 pediatric asthmatic patients having at least one respiratory infection episode, and 27,095 age- and sex-matched non-asthmatic children with respiratory infection served as controls. These patients were divided into groups with acetaminophen use, NSAID cyclooxygenase-1 (COX-1) use, and no antipyretic use. The rate of AE occurrence within the first 7 days after respiratory infection diagnosis was compared among the groups. Results: During a single episode of respiratory infection, asthmatic patients used fewer antipyretics than controls (48.51% vs. 55.50%, p
- Published
- 2020
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