1. Phenotypical characterization of human rhinovirus infections in severely premature children
- Author
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Bassem Kurdi, Dinesh K. Pillai, Gustavo Nino, Krishna Pancham, Natalia Isaza, Geovanny F. Perez, Rosemary Megalaa, Carlos E. Rodriguez-Martinez, and Shehlanoor Huseni
- Subjects
Male ,Pediatrics ,Rhinovirus ,medicine.disease_cause ,Human rhinovirus ,Hypoxemia ,0302 clinical medicine ,Medicine ,Respiratory Tract Infections ,Tachypnea ,education.field_of_study ,Respiratory distress ,Respiratory tract infections ,Pediatría ,lcsh:RJ1-570 ,Phenotype ,Child, Preschool ,Female ,medicine.symptom ,Prematurity ,Infant, Premature ,circulatory and respiratory physiology ,medicine.medical_specialty ,Ruidos respiratorios ,Population ,Article ,03 medical and health sciences ,030225 pediatrics ,Informes de casos ,Humans ,education ,Retrospective Studies ,human rhinovirus ,Picornaviridae Infections ,hypoxemia ,wheezing ,business.industry ,prematurity ,Infant, Newborn ,Infant ,lcsh:Pediatrics ,Airway obstruction ,medicine.disease ,respiratory tract diseases ,Airway Obstruction ,030228 respiratory system ,Pediatrics, Perinatology and Child Health ,business ,Airway - Abstract
Background Human Rhinovirus (HRV) has been identified as the most common cause of acute respiratory infections and hospitalizations in premature children. It is unclear if premature children are more susceptible to HRV due to their decreased pulmonary reserve or because they have enhanced lower airway reactivity to HRV. Methods We conducted a retrospective analysis of the clinical respiratory presentation of all PCR-confirmed HRV infections in full-term and premature children aged ≤3 years in our institution. Standardized respiratory distress scores were developed to examine lower airway obstruction (i.e., wheezing, hyperinflation, and sub-costal retractions) along with markers of decreased pulmonary reserve (hypoxemia and tachypnea) in young children with HRV infections. Demographic and clinical variables were obtained from reviewing electronic medical records (EMR). Results This study included a total of 205 children; 71% of these children were born full-term (>37 weeks gestation), 10% preterm (32–37 weeks) and 19% severely premature (
- Published
- 2018
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