4 results on '"Jacqueline A. Pongracic"'
Search Results
2. Race, Ancestry, and Development of Food-Allergen Sensitization in Early Childhood
- Author
-
Xiaobin Wang, Howard Bauchner, Melanie Fu, X. Hong, Xin Liu, Katherin Ortiz, Colleen Pearson, Jacqueline A. Pongracic, Rajesh Kumar, Hui Ju Tsai, and Guoying Wang
- Subjects
Male ,Gerontology ,Multivariate analysis ,Genotype ,medicine.disease_cause ,White People ,Cohort Studies ,Allergen ,Food allergy ,Humans ,Medicine ,Sensitization ,business.industry ,Urban Health ,Infant ,Health Status Disparities ,Hispanic or Latino ,Articles ,Odds ratio ,Immunoglobulin E ,medicine.disease ,Confidence interval ,Black or African American ,Logistic Models ,medicine.anatomical_structure ,Child, Preschool ,Multivariate Analysis ,Pediatrics, Perinatology and Child Health ,Cohort ,Female ,Self Report ,business ,Food Hypersensitivity ,Demography ,Cohort study - Abstract
OBJECTIVE: We examined whether the risk of food-allergen sensitization varied according to self-identified race or genetic ancestry. METHODS: We studied 1104 children (mean age: 2.7 years) from an urban multiethnic birth cohort. Food sensitization was defined as specific immunoglobulin E (sIgE) levels of ≥0.35 kilo–units of allergen (kUA)/L for any of 8 common food allergens. Multivariate logistic regression analyses were used to evaluate the associations of self-identified race and genetic ancestry with food sensitization. Analyses also examined associations with numbers of food sensitizations (0, 1 or 2, and ≥3 foods) and with logarithmically transformed allergen sIgE levels. RESULTS: In this predominantly minority cohort (60.9% black and 22.5% Hispanic), 35.5% of subjects exhibited food sensitizations. In multivariate models, both self-reported black race (odds ratio [OR]: 2.34 [95% confidence interval [CI]: 1.24–4.44]) and African ancestry (in 10% increments; OR: 1.07 [95% CI: 1.02–1.14]) were associated with food sensitization. Self-reported black race (OR: 3.76 [95% CI: 1.09–12.97]) and African ancestry (OR: 1.19 [95% CI: 1.07–1.32]) were associated with a high number (≥3) of food sensitizations. African ancestry was associated with increased odds of peanut sIgE levels of ≥5 kUA/L (OR: 1.25 [95% CI: 1.01–1.52]). Similar ancestry associations were seen for egg sIgE levels of ≥2 kUA/L (OR: 1.13 [95% CI: 1.01–1.27]) and milk sIgE levels of ≥5 kUA/L (OR: 1.24 [95% CI: 0.94–1.63]), although findings were not significant for milk. CONCLUSIONS: Black children were more likely to be sensitized to food allergens and were sensitized to more foods. African ancestry was associated with peanut sensitization.
- Published
- 2011
3. The prevalence, severity, and distribution of childhood food allergy in the United States
- Author
-
Rajesh Kumar, Ruchi Gupta, Elizabeth E. Springston, Manoj R. Warrier, Bridget Smith, Jacqueline A. Pongracic, and Jane L. Holl
- Subjects
Male ,Pediatrics ,medicine.medical_specialty ,Allergy ,Adolescent ,Cross-sectional study ,Logistic regression ,Severity of Illness Index ,Food allergy ,Severity of illness ,Epidemiology ,Prevalence ,Medicine ,Humans ,Epinephrine autoinjector ,Child ,business.industry ,Infant ,medicine.disease ,Confidence interval ,United States ,Cross-Sectional Studies ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,business ,Food Hypersensitivity ,Demography - Abstract
OBJECTIVE: The goal of this study was to better estimate the prevalence and severity of childhood food allergy in the United States. METHODS: A randomized, cross-sectional survey was administered electronically to a representative sample of US households with children from June 2009 to February 2010. Eligible participants included adults (aged 18 years or older) able to complete the survey in Spanish or English who resided in a household with at least 1 child younger than 18 years. Data were adjusted using both base and poststratification weights to account for potential biases from sampling design and nonresponse. Data were analyzed as weighted proportions to estimate prevalence and severity of food allergy. Multiple logistic regression models were constructed to identify characteristics significantly associated with outcomes. RESULTS: Data were collected for 40 104 children; incomplete responses for 1624 children were excluded, which yielded a final sample of 38 480. Food allergy prevalence was 8.0% (95% confidence interval [CI]: 7.6–8.3). Among children with food allergy, 38.7% had a history of severe reactions, and 30.4% had multiple food allergies. Prevalence according to allergen among food-allergic children was highest for peanut (25.2% [95% CI: 23.3–27.1]), followed by milk (21.1% [95% CI: 19.4–22.8]) and shellfish (17.2% [95% CI: 15.6–18.9]). Odds of food allergy were significantly associated with race, age, income, and geographic region. Disparities in food allergy diagnosis according to race and income were observed. CONCLUSIONS: Findings suggest that the prevalence and severity of childhood food allergy is greater than previously reported. Data suggest that disparities exist in the clinical diagnosis of disease.
- Published
- 2011
4. Food allergy knowledge, attitudes, and beliefs of primary care physicians
- Author
-
Jennifer S. Kim, Xiaobin Wang, Jacqueline A. Pongracic, Jane L. Holl, Ruchi Gupta, Elizabeth E. Springston, and Bridget Smith
- Subjects
Male ,medicine.medical_specialty ,Allergy ,Pediatrics ,Health Knowledge, Attitudes, Practice ,Nasal problems ,Attitude of Health Personnel ,Milk allergy ,Primary care ,Food allergy ,Health care ,medicine ,Humans ,Poisson Distribution ,Practice Patterns, Physicians' ,Child ,Probability ,Quality of Health Care ,business.industry ,Survey research ,Focus Groups ,medicine.disease ,United States ,Family medicine ,Child, Preschool ,Health Care Surveys ,Pediatrics, Perinatology and Child Health ,Multivariate Analysis ,Medical training ,Female ,Clinical Competence ,business ,Family Practice ,Food Hypersensitivity - Abstract
OBJECTIVE: To provide insight into food allergy knowledge and perceptions among pediatricians and family physicians in the United States. METHODS: A national sample of pediatricians and family physicians was recruited between April and July 2008 to complete the validated, Web-based Chicago Food Allergy Research Survey for Primary Care Physicians. Findings were analyzed to provide composite/itemized knowledge scores, describe attitudes and beliefs, and examine the effects of participant characteristics on response. RESULTS: The sample included 407 primary care physicians; 99% of the respondents reported providing care for food-allergic patients. Participants answered 61% of knowledge-based items correctly. Strengths and weaknesses were identified in each content domain evaluated by the survey. For example, 80% of physicians surveyed knew that the flu vaccine is unsafe for egg-allergic children, 90% recognized that the number of food-allergic children is increasing in the United States, and 80% were aware that there is no cure for food allergy. However, only 24% knew that oral food challenges may be used in the diagnosis of food allergy, 12% correctly rejected that chronic nasal problems are not symptom of food allergy, and 23% recognized that yogurts/cheeses from milk are unsafe for children with immunoglobulin E–mediated milk allergies. Fewer than 30% of the participants felt comfortable interpreting laboratory tests to diagnose food allergy or felt adequately prepared by their medical training to care for food-allergic children. CONCLUSIONS: Knowledge of food allergy among primary care physicians was fair. Opportunities for improvement exist, as acknowledged by participants' own perceptions of their clinical abilities in the management of food allergy.
- Published
- 2009
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.