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S Lee, A Peterson, CM Lohse, EP Hess, RL Campbell. J Allergy Clin Immunol Pract. 2017;5(5):1295–1301 To evaluate variables to help in the identification of patients who are at an increased risk for biphasic anaphylactic reactions in the emergency department (ED). The study included 807 patients in the ED with a total of 872 ED visits for anaphylaxis. The median age was 34 years, with 58% female patients and 26% pediatric subjects

RS Gupta, MM Walkner, M Greenhawt. J Allergy Clin Immunol Pract. 2016;4(5):956–962 To determine the prevalence of food sensitization and clinical food allergy among siblings of food-allergic children. Children were enrolled as part of the Chicago Family Cohort Food Allergy study. Eligible families had 1 index child with confirmed food allergy and at least 1 sibling participating in the study. There were 478 food-allergic children and 642 siblings. Of index children, 63.6% were male, and 50% were between the ages of 2 and 5 years. Of siblings, 66.5% were younger than the index child. A structured questionnaire-based interview was performed with each parent. Serum IgE (sIgE) values for 9 common food allergens …

SM van Dijk, H Gardarsdottir, M Wassenburg. J Allergy Clin Immunol Pract. 2016;4(5):926–931 To assess the impact of a diagnosis of penicillin allergy in hospitalized patients. The study included all patients (children and adults) admitted at the University Medical Center in Utrecht, the Netherlands, over a 1-year period who underwent a standardized pharmacotherapeutic interview. There were 997 patients with documentation of penicillin allergy (Pen-A) and 2939 patients without documentation of penicillin allergy (non–Pen-A). This was a prospective, matched cohort study. Patients were registered as having penicillin allergy if the history demonstrated either an evaluation by …

JL Friedlander, WJ Sheehan, SN Baxi. J Allergy Clin Immunol Pract. 2013;1(5):479–484 The goal of this study was to investigate the relation between food allergy and asthma morbidity in inner-city students with asthma. A total of 300 elementary school students with physician-diagnosed asthma were enrolled over a period of 6 years in the School Inner-City Asthma Study in the northeastern United States. Subjects were eligible if they had wheezing, used controller medications, or had unscheduled health care visits for asthma in the previous 12 months. This population was primarily a nonwhite (>95%), impoverished cohort …

P Amin, L Levin, T Epstein J Allergy Clin Immunol Pract. 2014;2(6):709–715 To determine whether the University of Cincinnati’s Asthma Predictive Index (ucAPI) and/or persistent wheezing by the age of 3 years are able to predict asthma at the age of 7 years, as confirmed by objective measures. Five hundred eighty-nine children were recruited from the Cincinnati Childhood Allergy and Air Pollution Study, a prospective birth cohort of children with at least 1 atopic parent; 54.8% were boys, 21.2% were African American, and 16.7% were from a household with yearly income

AC Wu, L Li, V Fung. J Allergy Clin Immunol Pract. 2014;2(5):607–613 To assess the risk of asthma exacerbation in children with asthma treated with various controller medications, including inhaled corticosteroids (ICS), leukotriene antagonists (LTRA), and ICS/long-acting β-agonist combinations (ICS-LABA). The study subjects included 26 191 controller-naive asthmatic children aged 4 to 17 years with uncontrolled asthma defined as at least 1 previous asthma exacerbation in the preceding year requiring an ED visit, hospitalization, or a short course of oral corticosteroids. Subjects were recruited from the databases of 6 private health plans (59%) and from the Tennessee Medicaid population (41%). This was a retrospective cohort study of …

D Colson, N Kalach, P Soulaines. J Allergy Clin Immunol Pract. 2014;2(5):587–593 The purpose of this study was to evaluate the impact of various elimination diets on the nutritional status of children with eosinophilic esophagitis (EoE). The study included 59 children consecutively referred to the pediatric gastroenterology department at the hospital Necker-Enfants Malades in Paris, France, who had nutritional assessment before and after a 2-month dietary therapy period without oral or topical corticosteroids. There were 37 boys and 22 girls ranging in age from 9 months to 15 years. Children with EoE were treated with a modified 6 …

WD Arroyave, FA Rabito, JC Carlson. J Allergy Clin Immunol Practice. 2013;1(5):501–508 The goal of this study was to examine the relationship between specific IgE (sIgE) to indoor allergens and asthma outcomes as defined according to emergency department (ED) visits and wheeze. Subjects included all participants in the 2005–2006 National Health and Nutrition Examination Survey who reported having current asthma. There were 351 children