1. Risk factors for invasive, early-onset Escherichia coli infections in the era of widespread intrapartum antibiotic use
- Author
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Schrag, Stephanie J., Hadler, James L., Arnold, Kathryn E., Martell-Cleary, Patricia, Reingold, Arthur, and Schuchat, Anne
- Subjects
Escherichia coli infections -- Risk factors ,Escherichia coli infections -- Development and progression ,Escherichia coli infections -- Drug therapy ,Antibiotics -- Usage - Abstract
OBJECTIVE. The goal was to evaluate risk factors for invasive Escherichia coli infections in the first week of life (early onset), focusing on the role of intrapartum antibiotic use. METHODS. We conducted a retrospective case-control study. Between 1997 and 2001, case infants, defined as infants RESULTS. Surveillance identified 132 E coli cases, including 68 ampicillin-resistant cases. The case fatality rate was 16% (21 of 132 cases). Two thirds of case infants were preterm, and 49% (64 of 132 infants) were born at [less than or equal to] 33 weeks of gestation. Fifty-three percent of case mothers (70 of 132 mothers) received intrapartum antibiotic therapy; 70% of those received ampicillin or penicillin. Low gestational age ([less than or equal to] 33 weeks), intrapartum fever, and membrane rupture of [greater than or equal to] 18 hours were associated with increased odds of early-onset E coli infection. Results were similar when case subjects were limited to those infected with ampicillin-resistant strains. Exposure to any intrapartum antibiotic treatment, [beta]-lactam antibiotic treatment, or [greater than or equal to] 4 hours of intrapartum antibiotic therapy was associated with increased odds of E coli infection and ampicillin-resistant infection in univariate analyses. Among preterm infants, intrapartum antibiotic exposure did not remain associated with either outcome in multivariable models. Among term infants, exposure to [greater than or equal to] 4 hours of intrapartum antibiotic therapy was associated with decreased odds of early-onset E coli infection. CONCLUSIONS. Exposure to intrapartum antibiotic therapy did not increase the odds of invasive, early-onset E coli infection. Intrapartum antibiotic therapy was effective in preventing E coli infection only among term infants. Key Words neonate, perinatal infection, ampicillin, preterm delivery, chemoprophylaxis, sepsis Abbreviations GBS--group B streptococcus ABCs--Active Bacterial Core Surveillance CI--confidence interval OR--odds ratio aOR--adjusted odds ratio, NEONATAL SEPSIS IS a leading infectious cause of infant morbidity and death. Group B streptococcal (GBS) sepsis emerged in the 1970s as a predominant cause of infections in the first [...]
- Published
- 2006