Search

Your search keyword '"D'Agostino, A."' showing total 440 results
Start Over Author "D'Agostino, A." Journal pediatric surgery international
440 results on '"D'Agostino, A."'

1. GAPS phase II: development and pilot results of the global assessment in pediatric surgery, an evidence-based pediatric surgical capacity assessment tool for low-resource settings

Author

Yousef, Yasmine, Cairo, Sarah, St-Louis, Etienne, Goodman, Laura F., Hamad, Doulia M., Baird, Robert, Smith, Emily R., Emil, Sherif, Laberge, Jean-Martin, Abdelmalak, Mohamed, Gathuy, Zipporah, Evans, Faye, Adel, Maryam Ghavami, Bertille, Ki K., Chitnis, Milind, Millano, Leecarlo, Nthumba, Peter, d’Agostino, Sergio, Cigliano, Bruno, Zea-Salazar, Luis, Ameh, Emmanuel, Ozgediz, Doruk, Guadagno, Elena, and Poenaru, Dan

Published
2024
Full Text
View/download PDF

8. Remote ischemic conditioning in necrotizing enterocolitis: study protocol of a multi-center phase II feasibility randomized controlled trial

Author

Ganji, Niloofar, Li, Bo, Ahmad, Irfan, Daneman, Alan, Deshpande, Poorva, Dhar, Vijay, Eaton, Simon, Faingold, Ricardo, Gauda, Estelle B., Hall, Nigel, Helou, Salhab el, Kabeer, Mustafa H., Kim, Jae H., King, Alice, Livingston, Michael H., Ng, Eugene, Offringa, Martin, Palleri, Elena, Walton, Mark, Wesson, David E., Wester, Tomas, Wijnen, Rene M. H., Willan, Andrew, Yankanah, Rosanna, Zozaya, Carlos, Shah, Prakesh S., and Pierro, Agostino

Published
2022
Full Text
View/download PDF

39. Argon inhalation attenuates systemic inflammation and rescues lung architecture during experimental neonatal sepsis.

Author

Balsamo, Felicia, Li, Bo, Chusilp, Sinobol, Lee, Dorothy, Biouss, George, Lee, Carol, Maynes, Jason T., and Pierro, Agostino

Subjects
NEONATAL sepsis, ARGON, PREMATURE infants, PNEUMONIA, RESPIRATORY therapy, NOBLE gases
Abstract

Purpose: Neonatal sepsis is a systemic inflammatory infection common in premature infants and a leading cause of mortality. Argon is an emerging interest in the field of noble gas therapy. Neonates with severe sepsis are frequently mechanically ventilated creating an opportunity for inhalation therapy. We aimed to investigate argon inhalation as a novel experimental therapy in neonatal sepsis. Methods: Sepsis was established in C57BL/6 neonatal mice by a lipopolysaccharide intraperitoneal injection on postnatal day 9. Septic pup mice were exposed to room air as well as non-septic controls. In the argon group, septic pup mice were exposed to argon (70% Ar, 30% O2) for 6 h in a temperature-controlled environment. Results: At 6 h, survival was significantly enhanced when septic mice received argon compared to septic controls. Serum profiles of cytokine release were significantly attenuated as well as lung architecture restored. Conclusions: Our findings suggest that argon inhalation as a novel treatment for neonatal sepsis, reducing mortality and counteracting the acute systemic inflammatory response in the blood and preserving the architecture of the lung. This research can contribute to a paradigm shift in the treatment and outcome of neonates with sepsis. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

43. Remote ischemic conditioning in necrotizing enterocolitis

Author

Niloofar Ganji, Bo Li, Irfan Ahmad, Alan Daneman, Poorva Deshpande, Vijay Dhar, Simon Eaton, Ricardo Faingold, Estelle B. Gauda, Nigel Hall, Salhab el Helou, Mustafa H. Kabeer, Jae H. Kim, Alice King, Michael H. Livingston, Eugene Ng, Martin Offringa, Elena Palleri, Mark Walton, David E. Wesson, Tomas Wester, Rene M. H. Wijnen, Andrew Willan, Rosanna Yankanah, Carlos Zozaya, Prakesh S. Shah, Agostino Pierro, and Pediatric Surgery

Subjects
Clinical Trials, Phase I as Topic, Infant, Newborn, Infant, Bayes Theorem, General Medicine, Intestines, Clinical Trials, Phase II as Topic, Treatment Outcome, Enterocolitis, Necrotizing, Ischemia, Pediatrics, Perinatology and Child Health, Feasibility Studies, Humans, Multicenter Studies as Topic, Surgery, Randomized Controlled Trials as Topic
Abstract

Purpose: Remote ischemic conditioning (RIC) is a maneuver involving brief cycles of ischemia reperfusion in an individual’s limb. In the early stage of experimental NEC, RIC decreased intestinal injury and prolonged survival by counteracting the derangements in intestinal microcirculation. A single-center phase I study demonstrated that the performance of RIC was safe in neonates with NEC. The aim of this phase II RCT was to evaluate the safety and feasibility of RIC, to identify challenges in recruitment, retainment, and to inform a phase III RCT to evaluate efficacy. Methods: RIC will be performed by trained research personnel and will consist of four cycles of limb ischemia (4-min via cuff inflation) followed by reperfusion (4-min via cuff deflation), repeated on two consecutive days post randomization. The primary endpoint of this RCT is feasibility and acceptability of recruiting and randomizing neonates within 24 h from NEC diagnosis as well as masking and completing the RIC intervention. Results: We created a novel international consortium for this trial and created a consensus on the diagnostic criteria for NEC and protocol for the trial. The phase II multicenter-masked feasibility RCT will be conducted at 12 centers in Canada, USA, Sweden, The Netherlands, UK, and Spain. The inclusion criteria are: gestational age < 33 weeks, weight ≥ 750 g, NEC receiving medical treatment, and diagnosis established within previous 24 h. Neonates will be randomized to RIC (intervention) or no-RIC (control) and will continue to receive standard management of NEC. We expect to recruit and randomize 40% of eligible patients in the collaborating centers (78 patients; 39/arm) in 30 months. Bayesian methods will be used to combine uninformative prior distributions with the corresponding observed proportions from this trial to determine posterior distributions for parameters of feasibility. Conclusions: The newly established NEC consortium has generated novel data on NEC diagnosis and defined the feasibility parameters for the introduction of a novel treatment in NEC. This phase II RCT will inform a future phase III RCT to evaluate the efficacy and safety of RIC in early-stage NEC.

Published
2022

49. Surgical site infection after open and laparoscopic surgery in children: a systematic review and meta-analysis

Author

George Biouss, Mashriq Alganabi, and Agostino Pierro

Subjects
Male, Laparoscopic surgery, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Operative Time, Fundoplication, Pyloromyotomy, Pyloric stenosis, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Pediatric surgery, medicine, Appendectomy, Humans, Surgical Wound Infection, Child, Randomized Controlled Trials as Topic, business.industry, Infant, Newborn, Infant, General Medicine, Odds ratio, Length of Stay, medicine.disease, Appendicitis, 3. Good health, Surgery, Inguinal hernia, Child, Preschool, Meta-analysis, Pediatrics, Perinatology and Child Health, Female, Laparoscopy, 030211 gastroenterology & hepatology, business
Abstract

Surgical site infections (SSIs) are the most common healthcare-associated infections in patients undergoing surgery. Various randomised control trials (RCTs) indicate that laparoscopic procedures can be associated with better outcomes compared to open procedures. However, how open versus laparoscopic approaches compare across various paediatric procedures with respect to SSI rate remains poorly defined. In this review, we examined RCTs that directly compare SSI rates after open versus laparoscopic operations for appendicitis, gastro-esophageal reflux, inguinal hernia, and pyloric stenosis. MEDLINE, Embase, and Web of Science were searched for RCTs comparing four types of open versus laparoscopic operations in children. The operations included appendectomy, fundoplication for gastro-esophageal reflux, inguinal hernia repair, or pyloromyotomy. 364 records were identified and screened, 54 full-text articles were assessed for eligibility, and 17 RCTs were included in the analysis. SSI rate was the primary outcome. Operative time and length of stay (LOS) were the secondary outcomes. A meta-analysis was conducted using RevMan 5.4 software. Laparoscopic appendectomy had a lower SSI rate than open appendectomy (odds ratio of 2.22 [1.19, 4.15] p = 0.01). Laparoscopic fundoplication for gastro-esophageal reflux, inguinal hernia repair, or pyloromyotomy for pyloric stenosis were not associated with lower SSI rate compared to open surgery. Operative time was shorter in open fundoplication (– 71.22 min [– 89.79, – 52.65] p

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results