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Your search keyword '"del Giudice Emanuele"' showing total 13 results
Start Over Author "del Giudice Emanuele" Journal pediatric research
13 results on '"del Giudice Emanuele"'

1. Euthyroid sick syndrome and its association with complications of type 1 diabetes mellitus onset

Author

Marzuillo, Pierluigi, primary, Iafusco, Dario, additional, Guarino, Stefano, additional, Di Sessa, Anna, additional, Zanfardino, Angela, additional, Piscopo, Alessia, additional, Luongo, Caterina, additional, Capalbo, Daniela, additional, Verde, Martina, additional, Aiello, Francesca, additional, Festa, Adalgisa, additional, Miraglia del Giudice, Emanuele, additional, and Grandone, Anna, additional

Published
2023
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2. Evolution of congenital anomalies of urinary tract in children with and without solitary kidney

Author

Marzuillo, Pierluigi, primary, Guarino, Stefano, additional, Sessa, Anna Di, additional, Liguori, Laura, additional, Rambaldi, Pier Francesco, additional, Belfiore, Maria Paola, additional, Umano, Giuseppina Rosaria, additional, Lauretta, Daria, additional, Dinardo, Giulio, additional, Miraglia del Giudice, Emanuele, additional, and Polito, Cesare, additional

Published
2021
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5. Continuous glucose monitoring profile during therapeutic hypothermia in encephalopathic infants with unfavorable outcome

Author

Montaldo, Paolo, primary, Caredda, Elisabetta, additional, Pugliese, Umberto, additional, Zanfardino, Angela, additional, Delehaye, Chiara, additional, Inserra, Emanuela, additional, Capozzi, Laura, additional, Chello, Giovanni, additional, Capristo, Carlo, additional, Miraglia Del Giudice, Emanuele, additional, and Iafusco, Dario, additional

Published
2020
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11. IGF2 Gene Variants and Risk of Hypertension in Obese Children and Adolescents

Author

Faienza, Maria F, primary, Santoro, Nicola, additional, Lauciello, Rosaria, additional, Calabrò, Raffaele, additional, Giordani, Lucia, additional, Di Salvo, Giovanni, additional, Ventura, Annamaria, additional, Delvecchio, Maurizio, additional, Perrone, Laura, additional, Del Giudice, Emanuele M, additional, and Cavallo, Luciano, additional

Published
2010
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12. Pediatric obesity-related non-alcoholic fatty liver disease: waist-to-height ratio best anthropometrical predictor

Author

Domenico Cozzolino, Anna Di Sessa, Marcella Pedullà, Emanuele Miraglia del Giudice, Pierluigi Marzuillo, Giuseppina Rosaria Umano, Anna Grandone, Umano, Giuseppina R, Grandone, Anna, Di Sessa, Anna, Cozzolino, Domenico, Pedullà, Marcella, Marzuillo, Pierluigi, and Del Giudice, Emanuele Miraglia

Subjects
Male, Pediatric Obesity, medicine.medical_specialty, Adolescent, Disease, Body Mass Index, Liver disorder, 03 medical and health sciences, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, Risk Factors, 030225 pediatrics, Internal medicine, medicine, Humans, Mass index, Child, Retrospective Studies, Waist-to-height ratio, Waist-Height Ratio, Anthropometry, business.industry, Fatty liver, nutritional and metabolic diseases, Non alcoholic, medicine.disease, Obesity, Pediatrics, Perinatology and Child Health, Female, business, 030217 neurology & neurosurgery
Abstract

BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in pediatric obesity. Our study aims to identify a predictive anthropometrical measure for NAFLD in obese children. METHODS We retrospectively enrolled children and adolescents with obesity. Physical, biochemical, and ultrasound assessments were available. ROC curve tests were performed to identify the best predictor of NAFLD among waist-to-height ratio (WHR), BMI z-score, and triponderal mass index (TMI, an anthropometric index recently associated with increased adiposity in children). Subsequently, a cut-off value was identified. RESULTS In total, 1900 children and adolescents (1011 with NAFLD) were included. WHR (AUC 0.62, 95% CI 0.59-0.64) was the best predictor of NAFLD compared to BMI z-score (AUC 0.58, 95% CI 0.55-0.60) and TMI (AUC 0.58, 95% CI 0.55-0.61). WHR ≥ 0.53 in boys and 0.63 in girls displayed the best sensitivity and specificity for NAFLD presence. In addition, children with high WHR showed a significantly higher risk of NAFLD (boys: OR 2.43, 95% CI 1.61-3.68, p

Published
2020
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13. Transmembrane 6 superfamily member 2 167K allele improves renal function in children with obesity

Author

Angela La Manna, Pierluigi Marzuillo, Anna Di Sessa, Emanuele Miraglia del Giudice, Grazia Cirillo, Stefano Guarino, Marcella Pedullà, Giuseppina Rosaria Umano, Marzuillo, Pierluigi, Di Sessa, Anna, Cirillo, Grazia, Rosaria Umano, Giuseppina, Pedullà, Marcella, La Manna, Angela, Guarino, Stefano, and Del Giudice, Emanuele Miraglia

Subjects
Male, medicine.medical_specialty, Adolescent, Genotype, Renal function, Disease, Kidney, digestive system, Gastroenterology, Polymorphism, Single Nucleotide, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, 030225 pediatrics, Diabetes mellitus, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Obesity, Allele, Child, Alleles, Ultrasonography, business.industry, Fatty liver, Homozygote, nutritional and metabolic diseases, Membrane Proteins, Lipase, medicine.disease, digestive system diseases, Pediatrics, Perinatology and Child Health, Female, business, 030217 neurology & neurosurgery, TM6SF2, Glomerular Filtration Rate
Abstract

The transmembrane 6 superfamily member 2 (TM6SF2) E167K polymorphism influences estimated glomerular filtration rate (eGFR) in adults without diabetes and without obesity. We aimed exploring the impact of this polymorphism on eGFR in children with obesity with and without non-alcoholic fatty liver disease (NAFLD). We genotyped 531 children with obesity for TM6SF2 E167K polymorphism. NAFLD was defined by ultrasound detected liver steatosis and/or ALT > 40 IU/L. Patients carrying the TM6SF2 167K allele showed higher eGFR levels compared with E167 homozygous patients both among subjects with and without NAFLD. A general linear model confirmed a direct and significant association of eGFR values with TM6SF2 genotype both in patients with and without NAFLD. This association, however, was stronger in patients with NAFLD. Children with obesity carrying the TM6SF2 167K allele show higher eGFR levels compared with E167 allele homozygous subjects, independently of NAFLD. A major effect of this polymorphism in the presence of NAFLD was captured.

Published
2019

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