1. Combined Treatment Strategies for Unconjugated Hyperbilirubinemia in Gunn Rats
- Subjects
INTESTINAL ABSORPTION ,LACTOSE-MALABSORPTION ,NEONATAL JAUNDICE ,CALCIUM-PHOSPHATE ,ORLISTAT TREATMENT ,BILE PIGMENTS ,CRIGLER-NAJJAR SYNDROME ,GUT TRANSIT-TIME ,URSODEOXYCHOLIC ACID ,DRUG-INTERACTIONS - Abstract
We recently demonstrated that acceleration of the gastrointestinal transit by polyethylene glycol (PEG) treats unconjugated hyperbilirubinemia in jaundiced Gunn rats. It is unclear whether acceleration of gastrointestinal transit also (partly) underlies the therapeutic effects of established hypobilirubinemic treatments or whether PEG cotreatment might enhance these effects. We treated Gunn rats with phototherapy (17 mu W/cm(2)/nm), orlistat (200 mg/kg chow), ursodeoxycholate (5 g/kg chow), or calcium phosphate (CaP) (20 g/kg chow) either as single treatment or in combination with PEG. Three weeks of phototherapy, orlistat, ursodeoxycholic acid, or CaP treatment decreased plasma unconjugated bilirubin (UCB) levels by 47, 27, 28, and 45%, respectively (each p
- Published
- 2011