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Your search keyword '"Kirton, Adam"' showing total 26 results
Start Over Author "Kirton, Adam" Journal pediatric neurology
26 results on '"Kirton, Adam"'

4. Congenital Malformations in Children With Cerebral Palsy: Is Prematurity Protective?

Author

Sévère, Marcel, primary, Ng, Pamela, additional, Messerlian, Carmen, additional, Andersen, John, additional, Buckley, David, additional, Fehlings, Darcy, additional, Kirton, Adam, additional, Koclas, Louise, additional, Pigeon, Nicole, additional, Van Rensburg, Esias, additional, Wood, Ellen, additional, Shevell, Michael, additional, and Oskoui, Maryam, additional

Published
2020
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10. Seizures and Outcome One Year After Neonatal and Childhood Cerebral Sinovenous Thrombosis.

Author

Mineyko, Aleksandra, Kirton, Adam, Billinghurst, Lori, Tatishvili, Nana Nino, Wintermark, Max, deVeber, Gabrielle, Fox, Christine, and SIPS Investigators

Abstract

Background: Pediatric cerebral sinovenous thrombosis is a treatable cause of brain injury, acute symptomatic seizures, and remote epilepsy. Our objective was to prospectively study epilepsy and outcomes in neonates and children one year after cerebral sinovenous thrombosis diagnosis.Methods: Patients with cerebral sinovenous thrombosis were enrolled prospectively from 21 international sites through the Seizures in Pediatric Stroke Study. Clinical data, including acute symptomatic seizures and cerebral sinovenous thrombosis risk factors, were collected at diagnosis. A neuroradiologist who was unaware of the diagnosis reviewed acute imaging. At one year, outcomes including seizure recurrence, epilepsy diagnosis, antiepileptic drug use, and modified Engel score were collected. Outcomes were assessed using the modified Rankin score and the King's Outcome Scale for Childhood Head Injury.Results: Twenty-four participants with cerebral sinovenous thrombosis were enrolled (67% male, 21% neonates). Headache was the most common presenting symptom in non-neonates (47%, nine of 19). Nine (37.5%) presented with acute symptomatic seizures. Six (25%; 95% confidence interval, 10% to 47%) developed epilepsy by one-year follow-up. No clinical predictors associated with epilepsy were identified. King's Outcome Scale for Childhood Head Injury and modified Rankin scores at one year were favorable in 71%. Half of the patients who developed epilepsy (three of six) did not have infarcts, hemorrhage, or seizures identified during the acute hospitalization.Conclusion: Our study provides a prospective estimate that epilepsy occurs in approximately one-quarter of patients by one year after diagnosis of cerebral sinovenous thrombosis. Later epilepsy can develop in the absence of acute seizures or parenchymal injury associated with the acute presentation. [ABSTRACT FROM AUTHOR]

Published
2020
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11. The Association Between Maternal Age and Cerebral Palsy Risk Factors

Author

Schneider, Rilla E., primary, Ng, Pamela, additional, Zhang, Xun, additional, Andersen, John, additional, Buckley, David, additional, Fehlings, Darcy, additional, Kirton, Adam, additional, Wood, Ellen, additional, van Rensburg, Esias, additional, Shevell, Michael I., additional, and Oskoui, Maryam, additional

Published
2018
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13. Dyslipidemia in Children With Arterial Ischemic Stroke: Prevalence and Risk Factors

Author

Sultan, Sally, primary, Dowling, Michael, additional, Kirton, Adam, additional, DeVeber, Gabrielle, additional, Linds, Alexandra, additional, Elkind, Mitchell S.V., additional, Bernard, Tim, additional, Hernandez, Marta, additional, Rivkin, Michael, additional, Kopyta, Ilona, additional, Ichord, Rebecca, additional, Benedict, Susan, additional, Mackay, Mark, additional, Zafeiriou, Dimitrios, additional, Troncoso, Monica, additional, Yager, Jerome, additional, Abraham, Lisa, additional, Lo, Warren, additional, Gonzalez, Veronica, additional, Saengpattrachai, Montri, additional, Chan, Anthony, additional, Abdallah, Abdallah, additional, Brankovic-Sreckovic, Vesna, additional, Kolk, Anneli, additional, Carpenter, Jessica, additional, Kovacevic, Gordana, additional, Amlie-Lefond, Catherine, additional, Steinlin, Maja, additional, Paolicchi, Juliann, additional, Carell, Monroe, additional, Bjornson, Bruce, additional, Kosofsky, Barry, additional, Wong, Virginia, additional, Pergami, Paola, additional, Friedman, Neil, additional, Guang, Yang, additional, Humphreys, Peter, additional, Nowak-Göttl, Ulrike, additional, Ferriero, Donna, additional, Xavier, Frederico, additional, Fryer, Robert, additional, Andrade Alveal, Lucila, additional, Altuna, Diana, additional, Felling, Ryan, additional, Pavlakis, Steven, additional, Grabowski, Eric, additional, Golomb, Meredith, additional, Noetzel, Michael, additional, Khoury, Chaouki, additional, Lerner, Norma, additional, Blair, Amanda, additional, and Rafay, Mubeen, additional

Published
2018
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14. Harnessing Neuroimaging Capability in Pediatric Stroke: Proceedings of the Stroke Imaging Laboratory for Children Workshop

Author

Dlamini, Nomazulu, primary, Wintermark, Max, additional, Fullerton, Heather, additional, Strother, Stephen, additional, Lee, Wayne, additional, Bjornson, Bruce, additional, Guilliams, Kristin P., additional, Miller, Steven, additional, Kirton, Adam, additional, Filippi, Christopher G., additional, Linds, Alexandra, additional, Askalan, Rand, additional, and deVeber, Gabrielle, additional

Published
2017
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15. Epidemiology and Outcomes of Arterial Ischemic Stroke in Children: The Canadian Pediatric Ischemic Stroke Registry

Author

deVeber, Gabrielle A., primary, Kirton, Adam, additional, Booth, Frances A., additional, Yager, Jerome Y., additional, Wirrell, Elaine C., additional, Wood, Ellen, additional, Shevell, Michael, additional, Surmava, Ann-Marie, additional, McCusker, Patricia, additional, Massicotte, M. Patricia, additional, MacGregor, Daune, additional, MacDonald, E. Athen, additional, Meaney, Brandon, additional, Levin, Simon, additional, Lemieux, Bernard G., additional, Jardine, Lawrence, additional, Humphreys, Peter, additional, David, Michèle, additional, Chan, Anthony K.C., additional, Buckley, David J., additional, and Bjornson, Bruce H., additional

Published
2017
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22. Rolandic Mitochondrial Encephalomyelopathy and MT-ND3 Mutations

Author

Werner, Klaus G.E., primary, Morel, Chantal F., additional, Kirton, Adam, additional, Benseler, Susanne M., additional, Shoffner, John M., additional, Addis, Jane B.L., additional, Robinson, Brian H., additional, Burrowes, Delilah M., additional, Blaser, Susan I., additional, Epstein, Leon G., additional, and Feigenbaum, Annette S.J., additional

Published
2009
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26. Risk Factors for Term-Born Spastic Diplegic Cerebral Palsy: A Case-Control Study.

Author

Marefi, Amaar, Husein, Nafisa, Dunbar, Mary, Dewey, Deborah, Letourneau, Nicole, Oskoui, Maryam, Kirton, Adam, and Shevell, Michael

Subjects
*CEREBRAL palsy, *DELIVERY (Obstetrics), *CEREBRAL anoxia-ischemia, *PREGNANCY complications, *VERTICAL transmission (Communicable diseases), *CESAREAN section, *FETAL anoxia
Abstract

To identify if a predetermined set of potential risk factors are associated with spastic diplegic cerebral palsy (SDCP) in term-born children. This is a case-control study with cases (n = 134) extracted from the Canadian Cerebral Palsy Registry (CCPR) and controls (n = 1950) from the Alberta Pregnancy Outcomes and Nutrition (APrON) study. Our primary variable was the SDCP phenotype in term-born children. Possible risk factors were selected a priori and include extreme maternal age (<19 or >35 years), pregnancy complications, maternal disease, substance use, perinatal infection, mode of delivery, perinatal adversity (i.e., neonatal encephalopathy presumably on the basis of intrapartum hypoxia-ischemia), sex, and birth weight. Multivariable analyses were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Multivariable analysis revealed associations between term-born SDCP and pregnancy complications (OR = 4.73; 95% CI = 1.91 to 10.56), maternal disease (OR = 2.52; 95% CI = 1.57 to 3.93), substance use (OR = 3.11; 95% CI = 2.10 to 4.55), perinatal infection (OR = 2.72; 95% CI 1.32 to 5.10), Caesarean section (OR = 2.35; 95% CI = 1.62 to 3.40), and perinatal adversity (OR = 2.91; 95% CI = 1.94 to 4.50). Multiple regression analysis revealed associations between SDCP and pregnancy complications (OR = 3.28; 95% CI 1.20 to 8.15), maternal disease (OR = 2.52; 95% CI 1.50 to 4.12), substance use (OR = 3.59; 95% CI 2.37 to 5.40), perinatal infection (OR = 3.78, 95% CI 1.71 to 7.72), Caesarean section (OR = 2.72; 95% CI 1.82 to 4.03), and perinatal adversity (OR = 4.16; 95% CI 2.67 to 6.70). Antenatal (pregnancy complications, maternal disease, substance use) and perinatal (infections, Caesarean section, and perinatal adversity) risk factors are associated with an increased risk of SDCP in term-born children, suggesting variable interactions between risk factors to provide a clinicopathologic framework that is different from SDCP observed in preterm-born children. [ABSTRACT FROM AUTHOR]

Published
2024
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