1. Increasing incidence of acute kidney injury in pediatric severe sepsis and related adverse hospital outcomes
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Khatana, Jasmine, Thavamani, Aravind, Umapathi, Krishna Kishore, Sankararaman, Senthilkumar, and Roy, Aparna
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Diagnosis ,Complications and side effects ,Risk factors ,Pediatric diseases -- Diagnosis -- Risk factors ,Acute kidney failure -- Risk factors -- Diagnosis ,Sepsis -- Diagnosis -- Complications and side effects ,Children -- Diseases ,Acute renal failure -- Risk factors -- Diagnosis ,Acute renal failure in children -- Diagnosis -- Risk factors - Abstract
Author(s): Jasmine Khatana [sup.1] , Aravind Thavamani [sup.2] , Krishna Kishore Umapathi [sup.3] , Senthilkumar Sankararaman [sup.2] , Aparna Roy [sup.1] Author Affiliations: (1) grid.67105.35, 0000 0001 2164 3847, Department [...], Background Pediatric severe sepsis (PSS) is associated with increased mortality, and acute kidney injury (AKI) is an independent risk factor of mortality in PSS. However, there is little data on impact of AKI on hospital outcomes in PSS. Methods We analyzed non-overlapping years of the Kids' Inpatient Database (KID) and National Inpatient Sample (NIS) database between 2003 and 2019 of all pediatric patients with severe sepsis between 1 and 18 years of age. Using ICD diagnosis codes, patients were divided into two groups based on AKI status and compared for outcomes measures including in-hospital mortality and healthcare resource utilization using length of stay and inflation-adjusted hospitalization charges. Results We analyzed 192,712 hospitalizations due to PSS during the 17-year period. Prevalence of AKI was 23.6% with overall increasing trend, P Graphical abstract
- Published
- 2023
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