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1. Prevalence of transmitted HIV-1 drug resistance mutations in children and adolescents in São Paulo, Brazil.

Author

Almeida FJ, Rodrigues R, Zaparoli MS, Berezin EN, Sáfadi MA, de Paula Ferreira JL, Lança AM, and de Macedo Brígido LF

Subjects
Adolescent, Brazil epidemiology, Child, Child, Preschool, Female, Genotype, HIV Infections epidemiology, HIV-1 genetics, HIV-1 isolation & purification, Humans, Infant, Infant, Newborn, Male, Prevalence, Drug Resistance, Viral, HIV Infections transmission, HIV Infections virology, HIV-1 drug effects, Mutation, Missense
Abstract

HIV drug resistance genotype testing, performed on 39 HIV-infected treatment-naive children from 2000 to 2011, identified 5 children (12.8%) with drug resistance mutations: 5.3% to nucleoside reverse transcriptase inhibitors, 5.3% to nonnucleoside reverse transcriptase inhibitors and 7.7% to protease inhibitors. There was a trend for increasing prevalence of drug resistance mutations during the 11-year study period.

Published
2012
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