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This case study explores the use of CD45RA+ depleted lymphocyte infusion as a potential treatment for refractory cytomegalovirus (CMV) disease in an infant with complete DiGeorge syndrome (cDGS). The patient, who had a severe T cell deficiency, initially received ganciclovir but developed resistance. Infusing CD45RA+ depleted CMV-specific lymphocytes from the patient's father resulted in a decrease in CMV viral load. However, the patient ultimately passed away from pneumonia and sepsis. The study suggests that CD45RA+ depleted lymphocyte infusion may be a viable option for treating refractory CMV disease in cDGS patients, but further research is needed. [Extracted from the article]