1. Feasibility and Accuracy of Cardiac Right-to-Left-Shunt Detection in Children by New Transpulmonary Ultrasound Dilution Method
- Author
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Nils Dennhardt, Philipp Beerbaum, Harald Köditz, M Boehne, Verena Paetzel, Mathias Baustert, Harald Bertram, and Dietmar Boethig
- Subjects
Heart Defects, Congenital ,Male ,Cardiac Catheterization ,medicine.medical_specialty ,Cardiac output ,Adolescent ,Heart disease ,Right-to-left shunt ,Indicator Dilution Techniques ,Hemodynamics ,Blood volume ,030204 cardiovascular system & hematology ,Sensitivity and Specificity ,03 medical and health sciences ,0302 clinical medicine ,030202 anesthesiology ,medicine.artery ,Internal medicine ,mental disorders ,medicine ,Humans ,Prospective Studies ,Cardiac Output ,Child ,Lung ,Ultrasonography ,Reproducibility ,business.industry ,Ultrasound ,Infant ,Reproducibility of Results ,Heart ,medicine.disease ,Surgery ,Cardiac surgery ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Cardiology ,Feasibility Studies ,Female ,Cardiology and Cardiovascular Medicine ,business ,Algorithms - Abstract
Transpulmonary ultrasound dilution (TPUD) method, a novel indicator dilution (ID) technique for cardiac output measurement, detects and quantifies shunts, both in children and adults. However, its accuracy and reproducibility in cardiac right-to-left-shunt (RLS) detection have not been investigated. In a prospective observational study, we assessed the validity of TPUD algorithm for RLS detection in children with congenital heart disease (CHD) and proven RLS in comparison with controls without shunts between February 2010 and October 2011. As TPUD algorithm was unknown, we tested ID curve morphology, appearance time (AT) and central blood volume index (CBVI) as diagnostic criteria. TPUD identified RLS correctly in all 16 RLS subjects [median age (range): 18 months (1 month–15 years 6 months)] and excluded RLS in all 26 controls [74 months (8 months to 17 years 4 months)]. AT was significantly shorter in RLS (P
- Published
- 2016