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Your search keyword '"Elisha Waldman"' showing total 2 results
Start Over Author "Elisha Waldman" Journal pediatric bloodcancer
2 results on '"Elisha Waldman"'

1. A sequential treatment algorithm for infants with stage 4s neuroblastoma and massive hepatomegaly

Author

Michael Weintraub, Shoshana Revel-Vilk, Eitan Gross, Elisha Waldman, Benjamin Z. Koplewitz, Arnold I. Freeman, and Allan I. Bloom

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Blood cancer, Neuroblastoma, Medicine, Humans, Stage (cooking), Neoplasm Staging, Retrospective Studies, Chemotherapy, business.industry, Infant, Newborn, Infant, Hematology, medicine.disease, Sequential treatment, Combined Modality Therapy, Surgery, Oncology, Pediatrics, Perinatology and Child Health, Stage 4S Neuroblastoma, Female, business, Progressive disease, Algorithms, Guarded prognosis, Hepatomegaly
Abstract

Infants with 4s neuroblastoma (NB) and massive hepatomegaly have a guarded prognosis and mortality approaches 30%. We report on eight patients with 4s NB and massive hepatomegaly treated with multiple modalities. One patient had spontaneous tumor regression. Three patients had progressive disease and responded to chemotherapy. Four patients progressed despite intravenous chemotherapy, of whom two died, and two were salvaged with hepatic intra-arterial chemoembolization. Treatment of infants with stage 4s NB with massive hepatomegaly should be individualized based on disease course. A sequential approach with observation, intravenous chemotherapy, and intra-arterial chemoembolization, may improve the outcome of these infants. Pediatr Blood Cancer 2012; 59: 182–184. © 2011 Wiley Periodicals, Inc.

Published
2011

2. A rare case of GATA1 negative chemoresistant acute megakaryocytic leukemia in an 8-month-old infant with trisomy 21

Author

Polina Stepensky, Michael Weintraub, Shoshana Revel-Vilk, Elisha Waldman, Shai Izraeli, Rebecca Brooks, and Igor B. Resnick

Subjects
Oncology, Male, medicine.medical_specialty, Down syndrome, Antineoplastic Agents, Disease, medicine.disease_cause, Fatal Outcome, Leukemia, Megakaryoblastic, Acute, Internal medicine, Rare case, medicine, Humans, GATA1 Transcription Factor, Mutation, business.industry, Infant, GATA1, Hematology, medicine.disease, Leukemia, Drug Resistance, Neoplasm, Pediatrics, Perinatology and Child Health, Immunology, Down Syndrome, business, GATA1 Mutation, Trisomy
Abstract

Children with Down syndrome (DS) have a unique form of acute megakaryocytic leukemia (AMKL) characterized by the presence of mutations in the GATA1 gene leading to increased chemosensitivity and a favorable outcome. We describe an 8-month-old male with DS who was diagnosed with AMKL without a mutation in the GATA1 gene. The patient was treated according to the DS-AML-regimen but his disease progressed and he succumbed 9 months later. This rare case of DS AMKL without a GATA1 mutation with an unfavorable outcome suggests that GATA1 testing may play a useful role in initial stratification. Pediatr Blood Cancer 2010;54:1048–1049 © 2010 Wiley-Liss, Inc.

Published
2010

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