1. Pediatric TAFRO syndrome: A multi-institution case series illustrating clinical challenges and excellent outcomes.
- Author
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Johnson AK, Goteti S, Devald B, Mestnik S, Ghosh T, Williams R, Doughty ES, Linden MA, Beckman A, Williams T, Richardson K, and Martinelli M
- Subjects
- Adolescent, Female, Humans, Infant, Male, Edema pathology, Edema etiology, Fever etiology, Syndrome, Castleman Disease pathology, Castleman Disease diagnosis, Castleman Disease therapy, Thrombocytopenia therapy, Thrombocytopenia diagnosis, Thrombocytopenia pathology
- Abstract
A rare lymphoproliferative disorder involving thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), renal dysfunction (R), and organomegaly (O), called TAFRO syndrome, was first reported in 2010. Considered a variant of idiopathic multicentric Castleman's disease, the recent discovery and rarity of this syndrome pose challenges to diagnosis and management. Herein, we review three pediatric cases, including an infant, that illustrate the heterogeneity of TAFRO syndrome. Despite differences in presentation and treatment responses, all patients experienced excellent outcomes. This multi-institutional case series highlights the need to work toward earlier diagnosis and improved long-term management recommendations for patients with TAFRO syndrome., (© 2024 The Author(s). Pediatric Blood & Cancer published by Wiley Periodicals LLC.)
- Published
- 2024
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