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Clinical anamnesis, in vivo provocation testing, and in vitro determination of allergen-specific IgE comprise the traditional three pillars of diagnosis of IgE-associated allergy. Specific IgE levels to the clinically relevant grass pollen allergens Phl p 1, Phl p 2, Phl p 5, and Phl p 6 were significantly higher in the group with moderate rhinitis compared to children having mild rhinitis (Figure A). B, The sum of major grass pollen allergen-specific IgE levels (sIgE [ISU] Phl p 1 + 2+5 + 6; y-axis) and C, the number of grass pollen allergens recognized by IgE (y-axis) of children with mild vs moderate rhinitis (x-axis) are displayed. [Extracted from the article]