1. Identification of IL13 C1923T as a Single Nucleotide Polymorphism for Asthma in Children from Mauritius
- Author
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Li Hua, Quan Hua Liu, Yi Xiao Bao, Ding Zhu Fang, Jing Yang Li, Kamleshun Ramphul, and Ruo Xu Ji
- Subjects
Pulmonary and Respiratory Medicine ,Genetics ,education.field_of_study ,business.industry ,Population ,Single-nucleotide polymorphism ,Bioinformatics ,medicine.disease ,CHI3L1 ,respiratory tract diseases ,Pediatrics, Perinatology and Child Health ,Genotype ,medicine ,MS4A2 ,Immunology and Allergy ,Population study ,SNP ,business ,education ,Original Research ,Asthma - Abstract
Background: Research increasingly suggests that asthma is a familial and hereditary disorder and that genetic and environmental factors play a key role in its pathogenesis. Objective: The aim of this study was to investigate the associations between 10 single nucleotide polymorphism (SNP) loci in the development of asthma in children from the Mauritian population. Methods: The study population consisted of 193 children with asthma and 189 healthy controls from the Mauritian population. Asthma was diagnosed in accordance with the American Thoracic Society criteria. TaqMan real-time quantitative polymerase chain reaction was used to detect the genotypes of the SNP loci. Results: No statistically significant differences (p>0.05) were found between the experimental and control group in genotype distribution among nine of the loci (MS4A2 E237G, MS4A2 C-109T, ADRB2 R16G, IL4RA Q551R, IL4RA I75V, IL4 C-590T, IL13 A2044G, IL13 C-1112T, and CHI3L1 C-131G). However, the frequency of IL13 C1923T TT in the asthma gro...
- Published
- 2015
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