1. Reduction in homocysteine by n-3 polyunsaturated fatty acids after 1 year in a randomised double-blind study following an acute myocardial infarction: no effect on endothelial adhesion properties
- Author
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Øyvind Hetland, Heidi Grundt, Dennis W.T. Nilsen, Mohammad Azam Mansoor, and Arne Nordøy
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Homocysteine ,Endothelium ,Intercellular Adhesion Molecule-1 ,Myocardial Infarction ,chemistry.chemical_compound ,Double-Blind Method ,Physiology (medical) ,Internal medicine ,E-selectin ,Fatty Acids, Omega-3 ,medicine ,Cell Adhesion ,Humans ,Myocardial infarction ,Aged ,chemistry.chemical_classification ,Aged, 80 and over ,biology ,C-reactive protein ,Hematology ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Immunology ,biology.protein ,Female ,Corn Oil ,Endothelium, Vascular ,Cell Adhesion Molecules ,Corn oil ,Polyunsaturated fatty acid - Abstract
We hypothesized that n–3 polyunsaturated fatty acids (n–3 PUFAs) as compared to corn oil administered for 1 year following an acute myocardial infarction (MI) may reduce plasma total homocysteine (p-tHcy), ultrasensitive C-reactive protein (µCRP), and the adhesive properties of the endothelium, expressed as soluble E-selectin (sE-selectin) and soluble intercellular adhesion molecule-1 (sICAM-1). In a prospective, randomised, double-blind study, 300 acute MI patients were allocated to highly concentrated n–3 PUFAs (n = 150) or corn oil (n = 150). After 1 year on treatment there was an intergroup difference in p-tHcy in favour of the n–3 group (n = 118), p = 0.022. However, sE-selectin, sICAM-1 and µCRP were unaffected by the treatment. In conclusion, reduction of p-tHcy by long-term n–3 PUFAs treatment was not associated with demonstrable effects on markers of endothelial adhesion properties.
- Published
- 2003